Enhanced MAPK signaling is essential for CSF3R induced leukemia

Both membrane-proximal and truncation mutations in CSF3R have recently been reported to drive the onset of chronic neutrophilic leukemia (CNL). Here we show that although truncation mutation alone can not induce leukemia, both proximal and compound mutations (proximal and truncation mutations on sam...

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Detalles Bibliográficos
Autores principales: Rohrabaugh, Sara, Kesarwani, Meenu, Kincaid, Zachary, Huber, Erika, Leddonne, Jennifer, Siddiqui, Zain, Khalifa, Yara, Komurov, Kakajan, Grimes, H. Leighton, Azam, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537052/
https://www.ncbi.nlm.nih.gov/pubmed/28031554
http://dx.doi.org/10.1038/leu.2016.376

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