Cargando…

Precision medicine: In need of guidance and surveillance

Precision medicine, currently a hotspot in mainstream medicine, has been strongly promoted in recent years. With rapid technological development, such as next-generation sequencing, and fierce competition in molecular targeted drug exploitation, precision medicine represents an advance in science an...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Jian-Zhen, Long, Jun-Yu, Wang, An-Qiang, Zheng, Ying, Zhao, Hai-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537174/
https://www.ncbi.nlm.nih.gov/pubmed/28811702
http://dx.doi.org/10.3748/wjg.v23.i28.5045
_version_ 1783254116518068224
author Lin, Jian-Zhen
Long, Jun-Yu
Wang, An-Qiang
Zheng, Ying
Zhao, Hai-Tao
author_facet Lin, Jian-Zhen
Long, Jun-Yu
Wang, An-Qiang
Zheng, Ying
Zhao, Hai-Tao
author_sort Lin, Jian-Zhen
collection PubMed
description Precision medicine, currently a hotspot in mainstream medicine, has been strongly promoted in recent years. With rapid technological development, such as next-generation sequencing, and fierce competition in molecular targeted drug exploitation, precision medicine represents an advance in science and technology; it also fulfills needs in public health care. The clinical translation and application of precision medicine - especially in the prevention and treatment of tumors - is far from satisfactory; however, the aims of precision medicine deserve approval. Thus, this medical approach is currently in its infancy; it has promising prospects, but it needs to overcome numbers of problems and deficiencies. It is expected that in addition to conventional symptoms and signs, precision medicine will define disease in terms of the underlying molecular characteristics and other environmental susceptibility factors. Those expectations should be realized by constructing a novel data network, integrating clinical data from individual patients and personal genomic background with existing research on the molecular makeup of diseases. In addition, multi-omics analysis and multi-discipline collaboration will become crucial elements in precision medicine. Precision medicine deserves strong support, and its development demands directed momentum. We propose three kinds of impetus (research, application and collaboration impetus) for such directed momentum toward promoting precision medicine and accelerating its clinical translation and application.
format Online
Article
Text
id pubmed-5537174
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Baishideng Publishing Group Inc
record_format MEDLINE/PubMed
spelling pubmed-55371742017-08-15 Precision medicine: In need of guidance and surveillance Lin, Jian-Zhen Long, Jun-Yu Wang, An-Qiang Zheng, Ying Zhao, Hai-Tao World J Gastroenterol Editorial Precision medicine, currently a hotspot in mainstream medicine, has been strongly promoted in recent years. With rapid technological development, such as next-generation sequencing, and fierce competition in molecular targeted drug exploitation, precision medicine represents an advance in science and technology; it also fulfills needs in public health care. The clinical translation and application of precision medicine - especially in the prevention and treatment of tumors - is far from satisfactory; however, the aims of precision medicine deserve approval. Thus, this medical approach is currently in its infancy; it has promising prospects, but it needs to overcome numbers of problems and deficiencies. It is expected that in addition to conventional symptoms and signs, precision medicine will define disease in terms of the underlying molecular characteristics and other environmental susceptibility factors. Those expectations should be realized by constructing a novel data network, integrating clinical data from individual patients and personal genomic background with existing research on the molecular makeup of diseases. In addition, multi-omics analysis and multi-discipline collaboration will become crucial elements in precision medicine. Precision medicine deserves strong support, and its development demands directed momentum. We propose three kinds of impetus (research, application and collaboration impetus) for such directed momentum toward promoting precision medicine and accelerating its clinical translation and application. Baishideng Publishing Group Inc 2017-07-28 2017-07-28 /pmc/articles/PMC5537174/ /pubmed/28811702 http://dx.doi.org/10.3748/wjg.v23.i28.5045 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Editorial
Lin, Jian-Zhen
Long, Jun-Yu
Wang, An-Qiang
Zheng, Ying
Zhao, Hai-Tao
Precision medicine: In need of guidance and surveillance
title Precision medicine: In need of guidance and surveillance
title_full Precision medicine: In need of guidance and surveillance
title_fullStr Precision medicine: In need of guidance and surveillance
title_full_unstemmed Precision medicine: In need of guidance and surveillance
title_short Precision medicine: In need of guidance and surveillance
title_sort precision medicine: in need of guidance and surveillance
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537174/
https://www.ncbi.nlm.nih.gov/pubmed/28811702
http://dx.doi.org/10.3748/wjg.v23.i28.5045
work_keys_str_mv AT linjianzhen precisionmedicineinneedofguidanceandsurveillance
AT longjunyu precisionmedicineinneedofguidanceandsurveillance
AT wanganqiang precisionmedicineinneedofguidanceandsurveillance
AT zhengying precisionmedicineinneedofguidanceandsurveillance
AT zhaohaitao precisionmedicineinneedofguidanceandsurveillance