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Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps
AIM: To investigate the relationship between non-alcoholic fatty liver disease (NAFLD) and colorectal adenomatous and hyperplastic polyps. METHODS: A retrospective cross-sectional study was conducted on 3686 individuals undergoing health checkups (2430 males and 1256 females). All subjects underwent...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537187/ https://www.ncbi.nlm.nih.gov/pubmed/28811715 http://dx.doi.org/10.3748/wjg.v23.i28.5206 |
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author | Chen, Qin-Fen Zhou, Xiao-Dong Sun, Yang-Jie Fang, Dan-Hong Zhao, Qian Huang, Jun-Hua Jin, Yin Wu, Jian-Sheng |
author_facet | Chen, Qin-Fen Zhou, Xiao-Dong Sun, Yang-Jie Fang, Dan-Hong Zhao, Qian Huang, Jun-Hua Jin, Yin Wu, Jian-Sheng |
author_sort | Chen, Qin-Fen |
collection | PubMed |
description | AIM: To investigate the relationship between non-alcoholic fatty liver disease (NAFLD) and colorectal adenomatous and hyperplastic polyps. METHODS: A retrospective cross-sectional study was conducted on 3686 individuals undergoing health checkups (2430 males and 1256 females). All subjects underwent laboratory testing, abdominal ultrasonography, colonoscopy, and an interview to ascertain the baseline characteristics and general state of health. Multinomial logistic regression analysis was performed to examine the association between NAFLD and the prevalence of colorectal adenomatous and hyperplastic polyps. Furthermore, the relationship was analyzed in different sex groups. Subgroup analysis was performed based on number, size, and location of colorectal polyps. RESULTS: The prevalence of colorectal polyps was 38.8% in males (16.2% for adenomatous polyps and 9.8% for hyperplastic polyps) and 19.3% in females (8.4% for adenomatous polyps and 3.9% for hyperplastic polyps). When adjusting for confounding variables, NAFLD was significantly associated with the prevalence of adenomatous polyps (OR = 1.28, 95%CI: 1.05-1.51, P < 0.05) and hyperplastic polyps (OR = 1.35, 95%CI: 1.01-1.82, P < 0.05). However, upon analyzing adenomatous and hyperplastic polyps in different sex groups, the significant association remained in males (OR = 1.53, 95%CI: 1.18-2.00, P < 0.05; OR = 1.42, 95%CI: 1.04-1.95, P < 0.05) but not in females (OR = 0.44, 95%CI: 0.18-1.04, P > 0.05; OR = 1.18, 95%CI: 0.50-2.78, P > 0.05). CONCLUSION: NAFLD is specifically associated with an increased risk of colorectal adenomatous and hyperplastic polyps in men. However, NAFLD may not be a significant factor in the prevalence of colorectal polyps in women. |
format | Online Article Text |
id | pubmed-5537187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-55371872017-08-15 Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps Chen, Qin-Fen Zhou, Xiao-Dong Sun, Yang-Jie Fang, Dan-Hong Zhao, Qian Huang, Jun-Hua Jin, Yin Wu, Jian-Sheng World J Gastroenterol Retrospective Study AIM: To investigate the relationship between non-alcoholic fatty liver disease (NAFLD) and colorectal adenomatous and hyperplastic polyps. METHODS: A retrospective cross-sectional study was conducted on 3686 individuals undergoing health checkups (2430 males and 1256 females). All subjects underwent laboratory testing, abdominal ultrasonography, colonoscopy, and an interview to ascertain the baseline characteristics and general state of health. Multinomial logistic regression analysis was performed to examine the association between NAFLD and the prevalence of colorectal adenomatous and hyperplastic polyps. Furthermore, the relationship was analyzed in different sex groups. Subgroup analysis was performed based on number, size, and location of colorectal polyps. RESULTS: The prevalence of colorectal polyps was 38.8% in males (16.2% for adenomatous polyps and 9.8% for hyperplastic polyps) and 19.3% in females (8.4% for adenomatous polyps and 3.9% for hyperplastic polyps). When adjusting for confounding variables, NAFLD was significantly associated with the prevalence of adenomatous polyps (OR = 1.28, 95%CI: 1.05-1.51, P < 0.05) and hyperplastic polyps (OR = 1.35, 95%CI: 1.01-1.82, P < 0.05). However, upon analyzing adenomatous and hyperplastic polyps in different sex groups, the significant association remained in males (OR = 1.53, 95%CI: 1.18-2.00, P < 0.05; OR = 1.42, 95%CI: 1.04-1.95, P < 0.05) but not in females (OR = 0.44, 95%CI: 0.18-1.04, P > 0.05; OR = 1.18, 95%CI: 0.50-2.78, P > 0.05). CONCLUSION: NAFLD is specifically associated with an increased risk of colorectal adenomatous and hyperplastic polyps in men. However, NAFLD may not be a significant factor in the prevalence of colorectal polyps in women. Baishideng Publishing Group Inc 2017-07-28 2017-07-28 /pmc/articles/PMC5537187/ /pubmed/28811715 http://dx.doi.org/10.3748/wjg.v23.i28.5206 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Retrospective Study Chen, Qin-Fen Zhou, Xiao-Dong Sun, Yang-Jie Fang, Dan-Hong Zhao, Qian Huang, Jun-Hua Jin, Yin Wu, Jian-Sheng Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps |
title | Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps |
title_full | Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps |
title_fullStr | Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps |
title_full_unstemmed | Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps |
title_short | Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps |
title_sort | sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps |
topic | Retrospective Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537187/ https://www.ncbi.nlm.nih.gov/pubmed/28811715 http://dx.doi.org/10.3748/wjg.v23.i28.5206 |
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