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CRISPR/Cas9-Mediated Knockin Application in Cell Therapy: A Non-viral Procedure for Bystander Treatment of Glioma in Mice

The use of non-viral procedures, together with CRISPR/Cas9 genome-editing technology, allows the insertion of single-copy therapeutic genes at pre-determined genomic sites, overcoming safety limitations resulting from random gene insertions of viral vectors with potential for genome damage. In this...

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Detalles Bibliográficos
Autores principales:	Meca-Cortés, Oscar, Guerra-Rebollo, Marta, Garrido, Cristina, Borrós, Salvador, Rubio, Nuria, Blanco, Jeronimo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537198/ https://www.ncbi.nlm.nih.gov/pubmed/28918039 http://dx.doi.org/10.1016/j.omtn.2017.07.012

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