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Codon-Optimized P1A-Encoding DNA Vaccine: Toward a Therapeutic Vaccination against P815 Mastocytoma

DNA vaccine can be modified to increase protein production and modulate immune response. To enhance the efficiency of a P815 mastocytoma DNA vaccine, the P1A gene sequence was optimized by substituting specific codons with synonymous ones while modulating the number of CpG motifs. The P815A murine a...

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Detalles Bibliográficos
Autores principales:	Lopes, Alessandra, Vanvarenberg, Kevin, Préat, Véronique, Vandermeulen, Gaëlle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537203/ https://www.ncbi.nlm.nih.gov/pubmed/28918040 http://dx.doi.org/10.1016/j.omtn.2017.07.011

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