Heterogeneity of tumor-infiltrating lymphocytes ascribed to local immune status rather than neoantigens by multi-omics analysis of glioblastoma multiforme

Hypothetically, intratumoral genomic heterogeneity has the potential to foster tumor-infiltrating lymphocyte (TIL) diversity; however, no study has directly tested this hypothesis by simultaneously investigating somatic mutations, TIL diversity, and immune response activity. Thus, we performed whole...

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Detalles Bibliográficos
Autores principales: Feng, Lin, Qian, Haipeng, Yu, Xuexin, Liu, Kan, Xiao, Ting, Zhang, Chengli, Kuang, Manchao, Cheng, Shujun, Li, Xueji, Wan, Jinghai, Zhang, Kaitai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537248/
https://www.ncbi.nlm.nih.gov/pubmed/28761058
http://dx.doi.org/10.1038/s41598-017-05538-z

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