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Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study

Central neurologic injury (CNI) causes dysfunctions not only in limbs but also in cognitive ability. We applied a novel peripheral nerve rewiring (PNR) surgical procedure to restore limb function. Here, we conducted a prospective study to develop estimates for the extent of preattentive processes to...

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Autores principales: Li, Tie, Hua, Xu-Yun, Zheng, Mou-Xiong, Zhu, Yu-Lan, Qiu, Yan-Qun, Shen, Yun-Dong, Xu, Jian-Guang, Gu, Yu-Dong, Xu, Wen-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537276/
https://www.ncbi.nlm.nih.gov/pubmed/28761096
http://dx.doi.org/10.1038/s41598-017-07263-z
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author Li, Tie
Hua, Xu-Yun
Zheng, Mou-Xiong
Zhu, Yu-Lan
Qiu, Yan-Qun
Shen, Yun-Dong
Xu, Jian-Guang
Gu, Yu-Dong
Xu, Wen-Dong
author_facet Li, Tie
Hua, Xu-Yun
Zheng, Mou-Xiong
Zhu, Yu-Lan
Qiu, Yan-Qun
Shen, Yun-Dong
Xu, Jian-Guang
Gu, Yu-Dong
Xu, Wen-Dong
author_sort Li, Tie
collection PubMed
description Central neurologic injury (CNI) causes dysfunctions not only in limbs but also in cognitive ability. We applied a novel peripheral nerve rewiring (PNR) surgical procedure to restore limb function. Here, we conducted a prospective study to develop estimates for the extent of preattentive processes to cognitive function changes in CNI patients after PNR. Auditory mismatch negativity (MMN) was measured in CNI patients who received the PNR surgery plus conventional rehabilitation treatment. During the 2-year follow-up, the MMN was enhanced with increased amplitude in the PNR plus rehabilitation group compared to the rehabilitation-only group as the experiment progressed, and progressive improvement in behavioural examination tests was also observed. Furthermore, we found a significant correlation between the changes in Fugl-Meyer assessment scale scores and in MMN amplitudes. These results suggested that PNR could affect the efficiency of pre-attention information processing synchronously with the recovery of motor function in the paralyzed arm of the in chronic CNI patients. Such electroencephalographic measures might provide a biological approach with which to distinguish patient subgroups after surgery, and the change in MMN may serve as an objective auxiliary index, indicating the degree of motor recovery and brain cognitive function.
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spelling pubmed-55372762017-08-03 Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study Li, Tie Hua, Xu-Yun Zheng, Mou-Xiong Zhu, Yu-Lan Qiu, Yan-Qun Shen, Yun-Dong Xu, Jian-Guang Gu, Yu-Dong Xu, Wen-Dong Sci Rep Article Central neurologic injury (CNI) causes dysfunctions not only in limbs but also in cognitive ability. We applied a novel peripheral nerve rewiring (PNR) surgical procedure to restore limb function. Here, we conducted a prospective study to develop estimates for the extent of preattentive processes to cognitive function changes in CNI patients after PNR. Auditory mismatch negativity (MMN) was measured in CNI patients who received the PNR surgery plus conventional rehabilitation treatment. During the 2-year follow-up, the MMN was enhanced with increased amplitude in the PNR plus rehabilitation group compared to the rehabilitation-only group as the experiment progressed, and progressive improvement in behavioural examination tests was also observed. Furthermore, we found a significant correlation between the changes in Fugl-Meyer assessment scale scores and in MMN amplitudes. These results suggested that PNR could affect the efficiency of pre-attention information processing synchronously with the recovery of motor function in the paralyzed arm of the in chronic CNI patients. Such electroencephalographic measures might provide a biological approach with which to distinguish patient subgroups after surgery, and the change in MMN may serve as an objective auxiliary index, indicating the degree of motor recovery and brain cognitive function. Nature Publishing Group UK 2017-07-31 /pmc/articles/PMC5537276/ /pubmed/28761096 http://dx.doi.org/10.1038/s41598-017-07263-z Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Li, Tie
Hua, Xu-Yun
Zheng, Mou-Xiong
Zhu, Yu-Lan
Qiu, Yan-Qun
Shen, Yun-Dong
Xu, Jian-Guang
Gu, Yu-Dong
Xu, Wen-Dong
Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study
title Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study
title_full Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study
title_fullStr Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study
title_full_unstemmed Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study
title_short Electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study
title_sort electrophysiological evidence for pre-attention information processing improvement in patients with central hemiplegic after peripheral nerve rewiring: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537276/
https://www.ncbi.nlm.nih.gov/pubmed/28761096
http://dx.doi.org/10.1038/s41598-017-07263-z
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