Modeling Dominant and Recessive Forms of Retinitis Pigmentosa by Editing Three Rhodopsin-Encoding Genes in Xenopus Laevis Using Crispr/Cas9

The utility of Xenopus laevis, a common research subject for developmental biology, retinal physiology, cell biology, and other investigations, has been limited by lack of a robust gene knockout or knock-down technology. Here we describe manipulation of the X. laevis genome using CRISPR/Cas9 to mode...

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Detalles Bibliográficos
Autores principales: Feehan, Joanna M., Chiu, Colette N., Stanar, Paloma, Tam, Beatrice M., Ahmed, Sheikh N., Moritz, Orson L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537283/
https://www.ncbi.nlm.nih.gov/pubmed/28761125
http://dx.doi.org/10.1038/s41598-017-07153-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537283/
https://www.ncbi.nlm.nih.gov/pubmed/28761125
http://dx.doi.org/10.1038/s41598-017-07153-4

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