A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors

NMDA receptors (NMDARs) contribute to several neuropathological processes. Novel positive allosteric modulators (PAMs) of NMDARs have recently been identified but their effects on NMDAR gating remain largely unknown. To this end, we tested the effect of a newly developed molecule UBP684 on GluN1/Glu...

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Detalles Bibliográficos
Autores principales: Chopra, Divyan A., Sapkota, Kiran, Irvine, Mark W., Fang, Guangyu, Jane, David E., Monaghan, Daniel T., Dravid, Shashank M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537304/
https://www.ncbi.nlm.nih.gov/pubmed/28761055
http://dx.doi.org/10.1038/s41598-017-07292-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537304/
https://www.ncbi.nlm.nih.gov/pubmed/28761055
http://dx.doi.org/10.1038/s41598-017-07292-8

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