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Astragaloside IV protects against podocyte injury via SERCA2-dependent ER stress reduction and AMPKα-regulated autophagy induction in streptozotocin-induced diabetic nephropathy

Aberrant endoplasmic reticulum (ER) stress and autophagy are associated with diabetic nephropathy. Here we investigated the effect of astragaloside IV (AS-IV) on the progression of diabetic nephropathy (DN) and the underlying mechanism involving ER stress and autophagy in streptozotocin (STZ)-induce...

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Detalles Bibliográficos
Autores principales:	Guo, Hengjiang, Wang, Yi, Zhang, Xuemei, Zang, Yingjun, Zhang, Yang, Wang, Li, Wang, Hao, Wang, Yunman, Cao, Aili, Peng, Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537362/ https://www.ncbi.nlm.nih.gov/pubmed/28761152 http://dx.doi.org/10.1038/s41598-017-07061-7

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