Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources

MiRNAs regulate gene expression by forming base pairing with mRNAs to inhibit the translation of those mRNAs. In many mammalian genomes each, about 2000 miRNAs were found to regulate roughly 60% of all the genes in that genome. Many experimental validations and computational predictions have been do...

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Detalles Bibliográficos
Autores principales: Bi, Zhao, Xue, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Genetics, Genomics and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537373/
https://www.ncbi.nlm.nih.gov/pubmed/28795090
http://dx.doi.org/10.1016/j.dib.2017.07.035
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author Bi, Zhao
Xue, Bin
author_facet Bi, Zhao
Xue, Bin
author_sort Bi, Zhao
collection PubMed
description MiRNAs regulate gene expression by forming base pairing with mRNAs to inhibit the translation of those mRNAs. In many mammalian genomes each, about 2000 miRNAs were found to regulate roughly 60% of all the genes in that genome. Many experimental validations and computational predictions have been done on miRNA:mRNA interactions. Nonetheless, the interactions from different sources are not always consistent. In this study, we integrated multiple online resources, including mirTarBase, TarBase, miRanda, miRDB, PITA, and TargetScan, and developed eleven large-scale datasets containing miRNA:mRNA interactions that are consistent among a specific subgroup of above-mentioned online resources. In addition, a new integrated confidence score was designed to show the significance for all the miRNA:mRNA interactions.
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spelling pubmed-55373732017-08-09 Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources Bi, Zhao Xue, Bin Data Brief Genetics, Genomics and Molecular Biology MiRNAs regulate gene expression by forming base pairing with mRNAs to inhibit the translation of those mRNAs. In many mammalian genomes each, about 2000 miRNAs were found to regulate roughly 60% of all the genes in that genome. Many experimental validations and computational predictions have been done on miRNA:mRNA interactions. Nonetheless, the interactions from different sources are not always consistent. In this study, we integrated multiple online resources, including mirTarBase, TarBase, miRanda, miRDB, PITA, and TargetScan, and developed eleven large-scale datasets containing miRNA:mRNA interactions that are consistent among a specific subgroup of above-mentioned online resources. In addition, a new integrated confidence score was designed to show the significance for all the miRNA:mRNA interactions. Elsevier 2017-07-20 /pmc/articles/PMC5537373/ /pubmed/28795090 http://dx.doi.org/10.1016/j.dib.2017.07.035 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Genetics, Genomics and Molecular Biology
Bi, Zhao
Xue, Bin
Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources
title Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources
title_full Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources
title_fullStr Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources
title_full_unstemmed Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources
title_short Consensus datasets of mouse miRNA-mRNA interactions from multiple online resources
title_sort consensus datasets of mouse mirna-mrna interactions from multiple online resources
topic Genetics, Genomics and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537373/
https://www.ncbi.nlm.nih.gov/pubmed/28795090
http://dx.doi.org/10.1016/j.dib.2017.07.035
work_keys_str_mv AT bizhao consensusdatasetsofmousemirnamrnainteractionsfrommultipleonlineresources
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