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Fractional amplitude of low-frequency fluctuations (fALFF) in post-stroke depression

Depression is a common outcome following stroke, associated with reduced quality of life and poorer recovery. Despite attempts to associate depression symptoms with specific lesion sites, the neural basis of post-stroke depression remains poorly understood. Resting state fMRI has provided new insigh...

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Autores principales: Egorova, Natalia, Veldsman, Michele, Cumming, Toby, Brodtmann, Amy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537409/
https://www.ncbi.nlm.nih.gov/pubmed/28794972
http://dx.doi.org/10.1016/j.nicl.2017.07.014
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author Egorova, Natalia
Veldsman, Michele
Cumming, Toby
Brodtmann, Amy
author_facet Egorova, Natalia
Veldsman, Michele
Cumming, Toby
Brodtmann, Amy
author_sort Egorova, Natalia
collection PubMed
description Depression is a common outcome following stroke, associated with reduced quality of life and poorer recovery. Despite attempts to associate depression symptoms with specific lesion sites, the neural basis of post-stroke depression remains poorly understood. Resting state fMRI has provided new insights into the neural underpinnings of post-stroke depression, but has been limited to connectivity analyses exploring interregional correlations in the time-course of activity. Other aspects of resting state BOLD signal remain unexamined. Measuring the amplitude of low frequency fluctuations allows the detection of spontaneous neural activity across the whole brain. It provides complementary information about frequency-specific local neural activity. We calculated the fractional amplitude of low frequency fluctuations (fALFF) in a group of 64 participants scanned 3 months post-stroke. Twenty showed depression symptoms when assessed with the Patient Health Questionnaire (PHQ-9). We performed analyses in both the typical 0.01–0.08 Hz range, as well as separately in the slow-5 (0.01–0.027 Hz) and slow-4 (0.027–0.073 Hz) ranges. We found significantly higher fALFF in the depressed compared to non-depressed participants in the left dorsolateral prefrontal cortex (DLPFC) and the right precentral gyrus, and a significant association between higher depression scores and higher fALFF in the left insula. The group differences were detected in the slow-5 fluctuations, while the association with depression severity was observed in the slow-4 range. We conclude that post-stroke depression can be characterised by aberrant spontaneous local neural activity, which in small samples could be a more sensitive measure than lesion volume and location.
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spelling pubmed-55374092017-08-09 Fractional amplitude of low-frequency fluctuations (fALFF) in post-stroke depression Egorova, Natalia Veldsman, Michele Cumming, Toby Brodtmann, Amy Neuroimage Clin Regular Article Depression is a common outcome following stroke, associated with reduced quality of life and poorer recovery. Despite attempts to associate depression symptoms with specific lesion sites, the neural basis of post-stroke depression remains poorly understood. Resting state fMRI has provided new insights into the neural underpinnings of post-stroke depression, but has been limited to connectivity analyses exploring interregional correlations in the time-course of activity. Other aspects of resting state BOLD signal remain unexamined. Measuring the amplitude of low frequency fluctuations allows the detection of spontaneous neural activity across the whole brain. It provides complementary information about frequency-specific local neural activity. We calculated the fractional amplitude of low frequency fluctuations (fALFF) in a group of 64 participants scanned 3 months post-stroke. Twenty showed depression symptoms when assessed with the Patient Health Questionnaire (PHQ-9). We performed analyses in both the typical 0.01–0.08 Hz range, as well as separately in the slow-5 (0.01–0.027 Hz) and slow-4 (0.027–0.073 Hz) ranges. We found significantly higher fALFF in the depressed compared to non-depressed participants in the left dorsolateral prefrontal cortex (DLPFC) and the right precentral gyrus, and a significant association between higher depression scores and higher fALFF in the left insula. The group differences were detected in the slow-5 fluctuations, while the association with depression severity was observed in the slow-4 range. We conclude that post-stroke depression can be characterised by aberrant spontaneous local neural activity, which in small samples could be a more sensitive measure than lesion volume and location. Elsevier 2017-07-18 /pmc/articles/PMC5537409/ /pubmed/28794972 http://dx.doi.org/10.1016/j.nicl.2017.07.014 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Egorova, Natalia
Veldsman, Michele
Cumming, Toby
Brodtmann, Amy
Fractional amplitude of low-frequency fluctuations (fALFF) in post-stroke depression
title Fractional amplitude of low-frequency fluctuations (fALFF) in post-stroke depression
title_full Fractional amplitude of low-frequency fluctuations (fALFF) in post-stroke depression
title_fullStr Fractional amplitude of low-frequency fluctuations (fALFF) in post-stroke depression
title_full_unstemmed Fractional amplitude of low-frequency fluctuations (fALFF) in post-stroke depression
title_short Fractional amplitude of low-frequency fluctuations (fALFF) in post-stroke depression
title_sort fractional amplitude of low-frequency fluctuations (falff) in post-stroke depression
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537409/
https://www.ncbi.nlm.nih.gov/pubmed/28794972
http://dx.doi.org/10.1016/j.nicl.2017.07.014
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