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Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas

BACKGROUND: The most prevalent form of bone cancer is osteosarcoma (OS), which is associated with poor prognosis in case of metastases formation. Mice harbouring liver kinase B1 (LKB1(+/−)) develop osteoblastoma-like tumours. Therefore, we asked whether loss of LKB1 gene has a role in the pathogenes...

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Detalles Bibliográficos
Autores principales:	Presneau, Nadège, Duhamel, Laure Alice, Ye, Hongtao, Tirabosco, Roberto, Flanagan, Adrienne M, Eskandarpour, Malihe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537492/ https://www.ncbi.nlm.nih.gov/pubmed/28632727 http://dx.doi.org/10.1038/bjc.2017.174

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