The role of primary tumour sidedness, EGFR gene copy number and EGFR promoter methylation in RAS/BRAF wild-type colorectal cancer patients receiving irinotecan/cetuximab

BACKGROUND: The data from randomised trials suggested that primary tumour sidedness could represent a prognostic and predictive factor in colorectal cancer (CRC) patients, particularly during treatment with anti-epidermal growth factor receptor (EGFR) therapy. However, an in-deep molecular selection...

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Detalles Bibliográficos
Autores principales: Demurtas, Laura, Puzzoni, Marco, Giampieri, Riccardo, Ziranu, Pina, Pusceddu, Valeria, Mandolesi, Alessandra, Cremolini, Chiara, Masi, Gianluca, Gelsomino, Fabio, Antoniotti, Carlotta, Loretelli, Cristian, Meriggi, Fausto, Zaniboni, Alberto, Falcone, Alfredo, Cascinu, Stefano, Scartozzi, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537494/
https://www.ncbi.nlm.nih.gov/pubmed/28632725
http://dx.doi.org/10.1038/bjc.2017.178

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