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Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals()

Background Depression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the FTO gene, suggesting its implication in the association between depression and obesity. Aims To confirm these findi...

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Autores principales: Rivera, Margarita, Locke, Adam E., Corre, Tanguy, Czamara, Darina, Wolf, Christiane, Ching-Lopez, Ana, Milaneschi, Yuri, Kloiber, Stefan, Cohen-Woods, Sara, Rucker, James, Aitchison, Katherine J., Bergmann, Sven, Boomsma, Dorret I., Craddock, Nick, Gill, Michael, Holsboer, Florian, Hottenga, Jouke-Jan, Korszun, Ania, Kutalik, Zoltan, Lucae, Susanne, Maier, Wolfgang, Mors, Ole, Müller-Myhsok, Bertram, Owen, Michael J., Penninx, Brenda W. J. H., Preisig, Martin, Rice, John, Rietschel, Marcella, Tozzi, Federica, Uher, Rudolf, Vollenweider, Peter, Waeber, Gerard, Willemsen, Gonneke, Craig, Ian W., Farmer, Anne E., Lewis, Cathryn M., Breen, Gerome, McGuffin, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal College of Psychiatrists 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537566/
https://www.ncbi.nlm.nih.gov/pubmed/28642257
http://dx.doi.org/10.1192/bjp.bp.116.183475
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author Rivera, Margarita
Locke, Adam E.
Corre, Tanguy
Czamara, Darina
Wolf, Christiane
Ching-Lopez, Ana
Milaneschi, Yuri
Kloiber, Stefan
Cohen-Woods, Sara
Rucker, James
Aitchison, Katherine J.
Bergmann, Sven
Boomsma, Dorret I.
Craddock, Nick
Gill, Michael
Holsboer, Florian
Hottenga, Jouke-Jan
Korszun, Ania
Kutalik, Zoltan
Lucae, Susanne
Maier, Wolfgang
Mors, Ole
Müller-Myhsok, Bertram
Owen, Michael J.
Penninx, Brenda W. J. H.
Preisig, Martin
Rice, John
Rietschel, Marcella
Tozzi, Federica
Uher, Rudolf
Vollenweider, Peter
Waeber, Gerard
Willemsen, Gonneke
Craig, Ian W.
Farmer, Anne E.
Lewis, Cathryn M.
Breen, Gerome
McGuffin, Peter
author_facet Rivera, Margarita
Locke, Adam E.
Corre, Tanguy
Czamara, Darina
Wolf, Christiane
Ching-Lopez, Ana
Milaneschi, Yuri
Kloiber, Stefan
Cohen-Woods, Sara
Rucker, James
Aitchison, Katherine J.
Bergmann, Sven
Boomsma, Dorret I.
Craddock, Nick
Gill, Michael
Holsboer, Florian
Hottenga, Jouke-Jan
Korszun, Ania
Kutalik, Zoltan
Lucae, Susanne
Maier, Wolfgang
Mors, Ole
Müller-Myhsok, Bertram
Owen, Michael J.
Penninx, Brenda W. J. H.
Preisig, Martin
Rice, John
Rietschel, Marcella
Tozzi, Federica
Uher, Rudolf
Vollenweider, Peter
Waeber, Gerard
Willemsen, Gonneke
Craig, Ian W.
Farmer, Anne E.
Lewis, Cathryn M.
Breen, Gerome
McGuffin, Peter
author_sort Rivera, Margarita
collection PubMed
description Background Depression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the FTO gene, suggesting its implication in the association between depression and obesity. Aims To confirm these findings by investigating the FTO polymorphism rs9939609 in new cohorts, and subsequently in a meta-analysis. Method The sample consists of 6902 individuals with depression and 6799 controls from three replication cohorts and two original discovery cohorts. Linear regression models were performed to test for association between rs9939609 and body mass index (BMI), and for the interaction between rs9939609 and depression status for an effect on BMI. Fixed and random effects meta-analyses were performed using METASOFT. Results In the replication cohorts, we observed a significant interaction between FTO, BMI and depression with fixed effects meta-analysis (β = 0.12, P = 2.7 × 10(−4)) and with the Han/Eskin random effects method (P = 1.4 × 10(−7)) but not with traditional random effects (β = 0.1, P = 0.35). When combined with the discovery cohorts, random effects meta-analysis also supports the interaction (β = 0.12, P = 0.027) being highly significant based on the Han/Eskin model (P = 6.9 × 10(−8)). On average, carriers of the risk allele who have depression have a 2.2% higher BMI for each risk allele, over and above the main effect of FTO. Conclusions This meta-analysis provides additional support for a significant interaction between FTO, depression and BMI, indicating that depression increases the effect of FTO on BMI. The findings provide a useful starting point in understanding the biological mechanism involved in the association between obesity and depression.
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spelling pubmed-55375662017-09-18 Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals() Rivera, Margarita Locke, Adam E. Corre, Tanguy Czamara, Darina Wolf, Christiane Ching-Lopez, Ana Milaneschi, Yuri Kloiber, Stefan Cohen-Woods, Sara Rucker, James Aitchison, Katherine J. Bergmann, Sven Boomsma, Dorret I. Craddock, Nick Gill, Michael Holsboer, Florian Hottenga, Jouke-Jan Korszun, Ania Kutalik, Zoltan Lucae, Susanne Maier, Wolfgang Mors, Ole Müller-Myhsok, Bertram Owen, Michael J. Penninx, Brenda W. J. H. Preisig, Martin Rice, John Rietschel, Marcella Tozzi, Federica Uher, Rudolf Vollenweider, Peter Waeber, Gerard Willemsen, Gonneke Craig, Ian W. Farmer, Anne E. Lewis, Cathryn M. Breen, Gerome McGuffin, Peter Br J Psychiatry Review Articles Background Depression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the FTO gene, suggesting its implication in the association between depression and obesity. Aims To confirm these findings by investigating the FTO polymorphism rs9939609 in new cohorts, and subsequently in a meta-analysis. Method The sample consists of 6902 individuals with depression and 6799 controls from three replication cohorts and two original discovery cohorts. Linear regression models were performed to test for association between rs9939609 and body mass index (BMI), and for the interaction between rs9939609 and depression status for an effect on BMI. Fixed and random effects meta-analyses were performed using METASOFT. Results In the replication cohorts, we observed a significant interaction between FTO, BMI and depression with fixed effects meta-analysis (β = 0.12, P = 2.7 × 10(−4)) and with the Han/Eskin random effects method (P = 1.4 × 10(−7)) but not with traditional random effects (β = 0.1, P = 0.35). When combined with the discovery cohorts, random effects meta-analysis also supports the interaction (β = 0.12, P = 0.027) being highly significant based on the Han/Eskin model (P = 6.9 × 10(−8)). On average, carriers of the risk allele who have depression have a 2.2% higher BMI for each risk allele, over and above the main effect of FTO. Conclusions This meta-analysis provides additional support for a significant interaction between FTO, depression and BMI, indicating that depression increases the effect of FTO on BMI. The findings provide a useful starting point in understanding the biological mechanism involved in the association between obesity and depression. Royal College of Psychiatrists 2017-08 /pmc/articles/PMC5537566/ /pubmed/28642257 http://dx.doi.org/10.1192/bjp.bp.116.183475 Text en © The Royal College of Psychiatrists 2017. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence.
spellingShingle Review Articles
Rivera, Margarita
Locke, Adam E.
Corre, Tanguy
Czamara, Darina
Wolf, Christiane
Ching-Lopez, Ana
Milaneschi, Yuri
Kloiber, Stefan
Cohen-Woods, Sara
Rucker, James
Aitchison, Katherine J.
Bergmann, Sven
Boomsma, Dorret I.
Craddock, Nick
Gill, Michael
Holsboer, Florian
Hottenga, Jouke-Jan
Korszun, Ania
Kutalik, Zoltan
Lucae, Susanne
Maier, Wolfgang
Mors, Ole
Müller-Myhsok, Bertram
Owen, Michael J.
Penninx, Brenda W. J. H.
Preisig, Martin
Rice, John
Rietschel, Marcella
Tozzi, Federica
Uher, Rudolf
Vollenweider, Peter
Waeber, Gerard
Willemsen, Gonneke
Craig, Ian W.
Farmer, Anne E.
Lewis, Cathryn M.
Breen, Gerome
McGuffin, Peter
Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals()
title Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals()
title_full Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals()
title_fullStr Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals()
title_full_unstemmed Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals()
title_short Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals()
title_sort interaction between the fto gene, body mass index and depression: meta-analysis of 13701 individuals()
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537566/
https://www.ncbi.nlm.nih.gov/pubmed/28642257
http://dx.doi.org/10.1192/bjp.bp.116.183475
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