Autophagy is required for cell survival under L-asparaginase-induced metabolic stress in acute lymphoblastic leukemia cells

L-asparaginase has been used for more than three decades in acute lymphoblastic leukemia (ALL) patients and remains an essential drug in the treatment of ALL. Poor response to L-asparaginase is associated with increased risk of therapeutic failure in ALL. However, both the metabolic perturbation and...

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Detalles Bibliográficos
Autores principales: Takahashi, H, Inoue, J, Sakaguchi, K, Takagi, M, Mizutani, S, Inazawa, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537607/
https://www.ncbi.nlm.nih.gov/pubmed/28346428
http://dx.doi.org/10.1038/onc.2017.59

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