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JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21

Cyclin D-CDK4/6 are the first cyclin-dependent kinase (CDK) complexes to be activated by mitogenic/oncogenic pathways. They have a central role in the cell multiplication decision and in its deregulation in cancer cells. We identified T172 phosphorylation of CDK4 rather than cyclin D accumulation as...

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Detalles Bibliográficos
Autores principales:	Colleoni, B, Paternot, S, Pita, J M, Bisteau, X, Coulonval, K, Davis, R J, Raspé, E, Roger, P P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537611/ https://www.ncbi.nlm.nih.gov/pubmed/28368408 http://dx.doi.org/10.1038/onc.2017.7

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