Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1α axis

Nucleus accumbens-associated protein-1 (NAC1), a nuclear factor of the BTB/POZ gene family, has emerging roles in cancer. In this study, we identified the NAC1-HDAC4-HIF-1α axis as an important pathway in regulating glycolysis and hypoxic adaptation in tumor cells. We show that nuclear NAC1 binds to...

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Detalles Bibliográficos
Autores principales: Zhang, Y, Ren, Y-J, Guo, L-C, Ji, C, Hu, J, Zhang, H-H, Xu, Q-H, Zhu, W-D, Ming, Z-J, Yuan, Y-S, Ren, X, Song, J, Yang, J-M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537617/
https://www.ncbi.nlm.nih.gov/pubmed/28319066
http://dx.doi.org/10.1038/onc.2017.51

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