Cargando…
Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells
Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The expression of the viral E6/E7 oncogenes plays a key role for HPV-linked oncogenesis. It recently has been found that low oxygen concentrations (“hypoxia”), as present in sub-regions of HPV-positive cancers, strongly af...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537666/ https://www.ncbi.nlm.nih.gov/pubmed/28678198 http://dx.doi.org/10.3390/v9070174 |
_version_ | 1783254225304682496 |
---|---|
author | Hoppe-Seyler, Karin Mändl, Julia Adrian, Svenja Kuhn, Bianca J. Hoppe-Seyler, Felix |
author_facet | Hoppe-Seyler, Karin Mändl, Julia Adrian, Svenja Kuhn, Bianca J. Hoppe-Seyler, Felix |
author_sort | Hoppe-Seyler, Karin |
collection | PubMed |
description | Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The expression of the viral E6/E7 oncogenes plays a key role for HPV-linked oncogenesis. It recently has been found that low oxygen concentrations (“hypoxia”), as present in sub-regions of HPV-positive cancers, strongly affect the interplay between the HPV oncogenes and their transformed host cell. As a result, a state of dormancy is induced in hypoxic HPV-positive cancer cells, which is characterized by a shutdown of viral oncogene expression and a proliferative arrest that can be reversed by reoxygenation. In this review, these findings are put into the context of the current concepts of both HPV-linked carcinogenesis and of the effects of hypoxia on tumor biology. Moreover, we discuss the consequences for the phenotype of HPV-positive cancer cells as well as for their clinical behavior and response towards established and prospective therapeutic strategies. |
format | Online Article Text |
id | pubmed-5537666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55376662017-08-04 Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells Hoppe-Seyler, Karin Mändl, Julia Adrian, Svenja Kuhn, Bianca J. Hoppe-Seyler, Felix Viruses Review Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The expression of the viral E6/E7 oncogenes plays a key role for HPV-linked oncogenesis. It recently has been found that low oxygen concentrations (“hypoxia”), as present in sub-regions of HPV-positive cancers, strongly affect the interplay between the HPV oncogenes and their transformed host cell. As a result, a state of dormancy is induced in hypoxic HPV-positive cancer cells, which is characterized by a shutdown of viral oncogene expression and a proliferative arrest that can be reversed by reoxygenation. In this review, these findings are put into the context of the current concepts of both HPV-linked carcinogenesis and of the effects of hypoxia on tumor biology. Moreover, we discuss the consequences for the phenotype of HPV-positive cancer cells as well as for their clinical behavior and response towards established and prospective therapeutic strategies. MDPI 2017-07-05 /pmc/articles/PMC5537666/ /pubmed/28678198 http://dx.doi.org/10.3390/v9070174 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hoppe-Seyler, Karin Mändl, Julia Adrian, Svenja Kuhn, Bianca J. Hoppe-Seyler, Felix Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells |
title | Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells |
title_full | Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells |
title_fullStr | Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells |
title_full_unstemmed | Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells |
title_short | Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells |
title_sort | virus/host cell crosstalk in hypoxic hpv-positive cancer cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537666/ https://www.ncbi.nlm.nih.gov/pubmed/28678198 http://dx.doi.org/10.3390/v9070174 |
work_keys_str_mv | AT hoppeseylerkarin virushostcellcrosstalkinhypoxichpvpositivecancercells AT mandljulia virushostcellcrosstalkinhypoxichpvpositivecancercells AT adriansvenja virushostcellcrosstalkinhypoxichpvpositivecancercells AT kuhnbiancaj virushostcellcrosstalkinhypoxichpvpositivecancercells AT hoppeseylerfelix virushostcellcrosstalkinhypoxichpvpositivecancercells |