Cargando…

A Branched-Chain Amino Acid-Related Metabolic Signature Characterizes Obese Adolescents with Non-Alcoholic Fatty Liver Disease

Dysregulation of several metabolite pathways, including branched-chain amino acids (BCAAs), are associated with Non-Alcoholic Fatty Liver Disease (NAFLD) and insulin resistance in adults, while studies in youth reported conflicting results. We explored whether, independently of obesity and insulin r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goffredo, Martina, Santoro, Nicola, Tricò, Domenico, Giannini, Cosimo, D’Adamo, Ebe, Zhao, Hongyu, Peng, Gang, Yu, Xiaoqing, Lam, Tukiet T., Pierpont, Bridget, Caprio, Sonia, Herzog, Raimund I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537762/ https://www.ncbi.nlm.nih.gov/pubmed/28640216 http://dx.doi.org/10.3390/nu9070642

Ejemplares similares

Central Role of Fatty Liver in the Pathogenesis of Insulin Resistance in Obese Adolescents
por: D'Adamo, Ebe, et al.
Publicado: (2010)

Decreased Transcription of ChREBP-α/β Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes: Associations With Insulin Resistance and Hyperglycemia
por: Kursawe, Romy, et al.
Publicado: (2013)

Type 2 Diabetes in Youth: Epidemiology and Pathophysiology
por: D’Adamo, Ebe, et al.
Publicado: (2011)

Glutamate–Serine–Glycine Index: A Novel Potential Biomarker in Pediatric Non-Alcoholic Fatty Liver Disease
por: Leonetti, Simone, et al.
Publicado: (2020)

Metabolic Features of Nonalcoholic Fatty Liver (NAFL) in Obese Adolescents: Findings From a Multiethnic Cohort
por: Tricò, Domenico, et al.
Publicado: (2018)

The Triglyceride-to-HDL Cholesterol Ratio: Association with insulin resistance in obese youths of different ethnic backgrounds
por: Giannini, Cosimo, et al.
Publicado: (2011)

Evidence for Early Defects in Insulin Sensitivity and Secretion Before the Onset of Glucose Dysregulation in Obese Youths : A Longitudinal Study
por: Giannini, Cosimo, et al.
Publicado: (2012)

Non-Alcoholic Fatty Liver Disease in Obese Youth With Insulin Resistance and Type 2 Diabetes
por: Scapaticci, Serena, et al.
Publicado: (2021)

Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis
por: Kursawe, Romy, et al.
Publicado: (2010)

Co-occurrence of Risk Alleles in or Near Genes Modulating Insulin Secretion Predisposes Obese Youth to Prediabetes
por: Giannini, Cosimo, et al.
Publicado: (2014)

Serum Levels of Receptors for Advanced Glycation End Products in Normal-Weight and Obese Children Born Small and Large for Gestational Age
por: Chiavaroli, Valentina, et al.
Publicado: (2012)

Longitudinal Effects of MRI-Measured Hepatic Steatosis on Biomarkers of Glucose Homeostasis and Hepatic Apoptosis in Obese Youth
por: Kim, Grace, et al.
Publicado: (2013)

The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic Insulin Sensitivity
por: Cropano, Catrina, et al.
Publicado: (2017)

A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents
por: Kursawe, Romy, et al.
Publicado: (2016)

The Liver in Children With Metabolic Syndrome
por: D'Adamo, Ebe, et al.
Publicado: (2019)

Growth differentiation factor 15 (GDF15) is associated with non-alcoholic fatty liver disease (NAFLD) in youth with overweight or obesity
por: Galuppo, Brittany, et al.
Publicado: (2022)

Hepatic Fat Accumulation Is Modulated by the Interaction between the rs738409 Variant in the PNPLA3 Gene and the Dietary Omega6/Omega3 PUFA Intake
por: Santoro, Nicola, et al.
Publicado: (2012)

The Association Between Hepatic Fat Content and Liver Injury in Obese Children and Adolescents: Effects of ethnicity, insulin resistance, and common gene variants
por: Santoro, Nicola, et al.
Publicado: (2013)

Relation of the degree of obesity in childhood to adipose tissue insulin resistance
por: Hagman, Emilia, et al.
Publicado: (2019)

Reprograming of proteasomal degradation by branched chain amino acid metabolism
por: Ravanelli, Sonia, et al.
Publicado: (2022)

Mechanistic Insights Into the Heterogeneity of Glucose Response Classes in Youths With Obesity: A Latent Class Trajectory Approach
por: Tricò, Domenico, et al.
Publicado: (2022)

A common variant in the Melatonin Receptor 1B gene (MTNR1B) is associated with increased risk of impaired fasting glucose (IFG) in obese youth
por: Zheng, Chao, et al.
Publicado: (2015)

Branched-chain amino acid metabolism in cancer
por: Ananieva, Elitsa A., et al.
Publicado: (2018)

Disorders of branched chain amino acid metabolism
por: Manoli, I., et al.
Publicado: (2016)

The coming of age for branched-chain amino acids
por: Gao, Chen, et al.
Publicado: (2021)

Immunometabolism – The Role of Branched-Chain Amino Acids
por: Yahsi, Berkay, et al.
Publicado: (2022)

Branched-Chain Amino Acids and Branched-Chain Keto Acids in Hyperammonemic States: Metabolism and as Supplements
por: Holeček, Milan
Publicado: (2020)

Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents
por: Jastreboff, Ania M., et al.
Publicado: (2016)

Differential Impact of Dietary Branched Chain and Aromatic Amino Acids on Chronic Kidney Disease Progression in Rats
por: Pillai, Samyuktha Muralidharan, et al.
Publicado: (2019)

Prediabetes in youth – mechanisms and biomarkers
por: Weiss, Ram, et al.
Publicado: (2017)

Branched Chain Amino Acids: Beyond Nutrition Metabolism
por: Nie, Cunxi, et al.
Publicado: (2018)

The effects of branch-chain amino acids on fatigue in the athletes
por: Vahid, Imanipour, et al.
Publicado: (2018)

Branched-chain amino acids are linked with iron metabolism
por: Enko, Dietmar, et al.
Publicado: (2020)

Branched-Chain Amino Acids and Risk of Breast Cancer
por: Zeleznik, Oana A, et al.
Publicado: (2021)

Research progress on branched-chain amino acid aminotransferases
por: Chen, Can, et al.
Publicado: (2023)

The Role of Branched-Chain Amino Acids and Branched-Chain α-Keto Acid Dehydrogenase Kinase in Metabolic Disorders
por: Du, Chuang, et al.
Publicado: (2022)

Association of Circulating Branched-Chain Amino Acids with Cardiovascular Diseases: A Mendelian Randomization Study
por: Xu, Huan, et al.
Publicado: (2023)

A pilot, short-term dietary manipulation of branched chain amino acids has modest influence on fasting levels of branched chain amino acids
por: Cavallaro, Nicole Landa, et al.
Publicado: (2016)

The Complex Role of Branched Chain Amino Acids in Diabetes and Cancer
por: O’Connell, Thomas M.
Publicado: (2013)

Branched-chain amino acids and the association with type 2 diabetes
por: Chen, Xiaoping, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_kspjmkl60pdtlkv4tpjl7drebe