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Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?

Vitamin C (Vit C) is considered to be a vital antioxidant molecule in the brain. Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modula...

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Autores principales: Kocot, Joanna, Luchowska-Kocot, Dorota, Kiełczykowska, Małgorzata, Musik, Irena, Kurzepa, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537779/
https://www.ncbi.nlm.nih.gov/pubmed/28654017
http://dx.doi.org/10.3390/nu9070659
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author Kocot, Joanna
Luchowska-Kocot, Dorota
Kiełczykowska, Małgorzata
Musik, Irena
Kurzepa, Jacek
author_facet Kocot, Joanna
Luchowska-Kocot, Dorota
Kiełczykowska, Małgorzata
Musik, Irena
Kurzepa, Jacek
author_sort Kocot, Joanna
collection PubMed
description Vitamin C (Vit C) is considered to be a vital antioxidant molecule in the brain. Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modulation of neurotransmission and antioxidant protection. The importance of Vit C for CNS function has been proven by the fact that targeted deletion of the sodium-vitamin C co-transporter in mice results in widespread cerebral hemorrhage and death on post-natal day one. Since neurological diseases are characterized by increased free radical generation and the highest concentrations of Vit C in the body are found in the brain and neuroendocrine tissues, it is suggested that Vit C may change the course of neurological diseases and display potential therapeutic roles. The aim of this review is to update the current state of knowledge of the role of vitamin C on neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis and amyotrophic sclerosis, as well as psychiatric disorders including depression, anxiety and schizophrenia. The particular attention is attributed to understanding of the mechanisms underlying possible therapeutic properties of ascorbic acid in the presented disorders.
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spelling pubmed-55377792017-08-04 Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders? Kocot, Joanna Luchowska-Kocot, Dorota Kiełczykowska, Małgorzata Musik, Irena Kurzepa, Jacek Nutrients Review Vitamin C (Vit C) is considered to be a vital antioxidant molecule in the brain. Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modulation of neurotransmission and antioxidant protection. The importance of Vit C for CNS function has been proven by the fact that targeted deletion of the sodium-vitamin C co-transporter in mice results in widespread cerebral hemorrhage and death on post-natal day one. Since neurological diseases are characterized by increased free radical generation and the highest concentrations of Vit C in the body are found in the brain and neuroendocrine tissues, it is suggested that Vit C may change the course of neurological diseases and display potential therapeutic roles. The aim of this review is to update the current state of knowledge of the role of vitamin C on neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis and amyotrophic sclerosis, as well as psychiatric disorders including depression, anxiety and schizophrenia. The particular attention is attributed to understanding of the mechanisms underlying possible therapeutic properties of ascorbic acid in the presented disorders. MDPI 2017-06-27 /pmc/articles/PMC5537779/ /pubmed/28654017 http://dx.doi.org/10.3390/nu9070659 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kocot, Joanna
Luchowska-Kocot, Dorota
Kiełczykowska, Małgorzata
Musik, Irena
Kurzepa, Jacek
Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?
title Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?
title_full Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?
title_fullStr Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?
title_full_unstemmed Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?
title_short Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?
title_sort does vitamin c influence neurodegenerative diseases and psychiatric disorders?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537779/
https://www.ncbi.nlm.nih.gov/pubmed/28654017
http://dx.doi.org/10.3390/nu9070659
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