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Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?
Vitamin C (Vit C) is considered to be a vital antioxidant molecule in the brain. Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modula...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537779/ https://www.ncbi.nlm.nih.gov/pubmed/28654017 http://dx.doi.org/10.3390/nu9070659 |
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author | Kocot, Joanna Luchowska-Kocot, Dorota Kiełczykowska, Małgorzata Musik, Irena Kurzepa, Jacek |
author_facet | Kocot, Joanna Luchowska-Kocot, Dorota Kiełczykowska, Małgorzata Musik, Irena Kurzepa, Jacek |
author_sort | Kocot, Joanna |
collection | PubMed |
description | Vitamin C (Vit C) is considered to be a vital antioxidant molecule in the brain. Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modulation of neurotransmission and antioxidant protection. The importance of Vit C for CNS function has been proven by the fact that targeted deletion of the sodium-vitamin C co-transporter in mice results in widespread cerebral hemorrhage and death on post-natal day one. Since neurological diseases are characterized by increased free radical generation and the highest concentrations of Vit C in the body are found in the brain and neuroendocrine tissues, it is suggested that Vit C may change the course of neurological diseases and display potential therapeutic roles. The aim of this review is to update the current state of knowledge of the role of vitamin C on neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis and amyotrophic sclerosis, as well as psychiatric disorders including depression, anxiety and schizophrenia. The particular attention is attributed to understanding of the mechanisms underlying possible therapeutic properties of ascorbic acid in the presented disorders. |
format | Online Article Text |
id | pubmed-5537779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55377792017-08-04 Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders? Kocot, Joanna Luchowska-Kocot, Dorota Kiełczykowska, Małgorzata Musik, Irena Kurzepa, Jacek Nutrients Review Vitamin C (Vit C) is considered to be a vital antioxidant molecule in the brain. Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modulation of neurotransmission and antioxidant protection. The importance of Vit C for CNS function has been proven by the fact that targeted deletion of the sodium-vitamin C co-transporter in mice results in widespread cerebral hemorrhage and death on post-natal day one. Since neurological diseases are characterized by increased free radical generation and the highest concentrations of Vit C in the body are found in the brain and neuroendocrine tissues, it is suggested that Vit C may change the course of neurological diseases and display potential therapeutic roles. The aim of this review is to update the current state of knowledge of the role of vitamin C on neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, multiple sclerosis and amyotrophic sclerosis, as well as psychiatric disorders including depression, anxiety and schizophrenia. The particular attention is attributed to understanding of the mechanisms underlying possible therapeutic properties of ascorbic acid in the presented disorders. MDPI 2017-06-27 /pmc/articles/PMC5537779/ /pubmed/28654017 http://dx.doi.org/10.3390/nu9070659 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kocot, Joanna Luchowska-Kocot, Dorota Kiełczykowska, Małgorzata Musik, Irena Kurzepa, Jacek Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders? |
title | Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders? |
title_full | Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders? |
title_fullStr | Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders? |
title_full_unstemmed | Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders? |
title_short | Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders? |
title_sort | does vitamin c influence neurodegenerative diseases and psychiatric disorders? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537779/ https://www.ncbi.nlm.nih.gov/pubmed/28654017 http://dx.doi.org/10.3390/nu9070659 |
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