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Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study

Obesity is considered to be a low-grade chronic inflammatory process, which is associated with cardiovascular and metabolic diseases. An integral evaluation of the effects of ferulic acid on biomarkers of glucose dysregulation, dyslipidemia, inflammation, and antioxidant potential induced by a high-...

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Autores principales: Salazar-López, Norma Julieta, Astiazarán-García, Humberto, González-Aguilar, Gustavo A., Loarca-Piña, Guadalupe, Ezquerra-Brauer, Josafat-Marina, Domínguez Avila, J. Abraham, Robles-Sánchez, Maribel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537790/
https://www.ncbi.nlm.nih.gov/pubmed/28661434
http://dx.doi.org/10.3390/nu9070675
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author Salazar-López, Norma Julieta
Astiazarán-García, Humberto
González-Aguilar, Gustavo A.
Loarca-Piña, Guadalupe
Ezquerra-Brauer, Josafat-Marina
Domínguez Avila, J. Abraham
Robles-Sánchez, Maribel
author_facet Salazar-López, Norma Julieta
Astiazarán-García, Humberto
González-Aguilar, Gustavo A.
Loarca-Piña, Guadalupe
Ezquerra-Brauer, Josafat-Marina
Domínguez Avila, J. Abraham
Robles-Sánchez, Maribel
author_sort Salazar-López, Norma Julieta
collection PubMed
description Obesity is considered to be a low-grade chronic inflammatory process, which is associated with cardiovascular and metabolic diseases. An integral evaluation of the effects of ferulic acid on biomarkers of glucose dysregulation, dyslipidemia, inflammation, and antioxidant potential induced by a high-fat diet (HFD) in rats was carried out. Three groups of male Wistar rats (six per group) consumed a basal diet (BD), which was supplemented with either lard at 310 g/kg (HFD) or lard and ferulic acid at 2 g/kg (HFD + FA), ad libitum for eight weeks. Body weight gain, hyperplasia, and hypertrophy in abdominal fat tissues were higher in the HFD group than in the HFD+FA group. The rats fed a HFD + FA significantly inhibited the increase in plasma lipids and glucose, compared with the HFD group. Biomarkers associated with inflammation were found at higher concentrations in the serum of rats fed a HFD than the HFD + FA group. Plasma antioxidant levels were lower in HFD rats compared to rats fed the HFD + FA. These results suggest that ferulic acid improves the obesogenic status induced by HFD, and we elucidated the integral effects of ferulic acid on a biological system.
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spelling pubmed-55377902017-08-04 Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study Salazar-López, Norma Julieta Astiazarán-García, Humberto González-Aguilar, Gustavo A. Loarca-Piña, Guadalupe Ezquerra-Brauer, Josafat-Marina Domínguez Avila, J. Abraham Robles-Sánchez, Maribel Nutrients Article Obesity is considered to be a low-grade chronic inflammatory process, which is associated with cardiovascular and metabolic diseases. An integral evaluation of the effects of ferulic acid on biomarkers of glucose dysregulation, dyslipidemia, inflammation, and antioxidant potential induced by a high-fat diet (HFD) in rats was carried out. Three groups of male Wistar rats (six per group) consumed a basal diet (BD), which was supplemented with either lard at 310 g/kg (HFD) or lard and ferulic acid at 2 g/kg (HFD + FA), ad libitum for eight weeks. Body weight gain, hyperplasia, and hypertrophy in abdominal fat tissues were higher in the HFD group than in the HFD+FA group. The rats fed a HFD + FA significantly inhibited the increase in plasma lipids and glucose, compared with the HFD group. Biomarkers associated with inflammation were found at higher concentrations in the serum of rats fed a HFD than the HFD + FA group. Plasma antioxidant levels were lower in HFD rats compared to rats fed the HFD + FA. These results suggest that ferulic acid improves the obesogenic status induced by HFD, and we elucidated the integral effects of ferulic acid on a biological system. MDPI 2017-06-29 /pmc/articles/PMC5537790/ /pubmed/28661434 http://dx.doi.org/10.3390/nu9070675 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Salazar-López, Norma Julieta
Astiazarán-García, Humberto
González-Aguilar, Gustavo A.
Loarca-Piña, Guadalupe
Ezquerra-Brauer, Josafat-Marina
Domínguez Avila, J. Abraham
Robles-Sánchez, Maribel
Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study
title Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study
title_full Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study
title_fullStr Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study
title_full_unstemmed Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study
title_short Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study
title_sort ferulic acid on glucose dysregulation, dyslipidemia, and inflammation in diet-induced obese rats: an integrated study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537790/
https://www.ncbi.nlm.nih.gov/pubmed/28661434
http://dx.doi.org/10.3390/nu9070675
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