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Calcium Intake and the Risk of Ovarian Cancer: A Meta-Analysis

Several epidemiological studies have evaluated the association between calcium intake and the risk of ovarian cancer. However, the results of these studies remain controversial. Thus, we performed a meta-analysis to explore the association between calcium intake and the risk of ovarian cancer. Pubme...

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Autores principales: Song, Xingxing, Li, Zongyao, Ji, Xinqiang, Zhang, Dongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537794/
https://www.ncbi.nlm.nih.gov/pubmed/28665326
http://dx.doi.org/10.3390/nu9070679
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author Song, Xingxing
Li, Zongyao
Ji, Xinqiang
Zhang, Dongfeng
author_facet Song, Xingxing
Li, Zongyao
Ji, Xinqiang
Zhang, Dongfeng
author_sort Song, Xingxing
collection PubMed
description Several epidemiological studies have evaluated the association between calcium intake and the risk of ovarian cancer. However, the results of these studies remain controversial. Thus, we performed a meta-analysis to explore the association between calcium intake and the risk of ovarian cancer. Pubmed, Embase and Web of Science were searched for eligible publications up to April 2017. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using the random-effects model. Small-study effect was estimated using Egger’s test and the funnel plot. Among 15 epidemiological studies involving 493,415 participants and 7453 cases eligible for this meta-analysis, 13 studies were about dietary calcium intake, 4 studies about dairy calcium intake and 7 studies about dietary plus supplemental calcium intake. When comparing the highest with the lowest intake, the pooled RRs of ovarian cancer were 0.80 (95% CI 0.72–0.89) for dietary calcium, 0.80 (95% CI 0.66–0.98) for dairy calcium and 0.90 (95% CI 0.65–1.24) for dietary plus supplemental calcium, respectively. Dietary calcium was significantly associated with a reduced risk of ovarian cancer among cohort studies (RR = 0.86, 95% CI 0.74–0.99) and among case-control studies (RR = 0.75, 95% CI 0.64–0.89). In subgroup analysis by ovarian cancer subtypes, we found a statistically significant association between the dietary calcium (RR = 0.78, 95% CI 0.69–0.88) and the risk of epithelial ovarian cancer (EOC). This meta-analysis indicated that increased calcium intake might be inversely associated with the risk of ovarian cancer; this still needs to be confirmed by larger prospective cohort studies.
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spelling pubmed-55377942017-08-04 Calcium Intake and the Risk of Ovarian Cancer: A Meta-Analysis Song, Xingxing Li, Zongyao Ji, Xinqiang Zhang, Dongfeng Nutrients Review Several epidemiological studies have evaluated the association between calcium intake and the risk of ovarian cancer. However, the results of these studies remain controversial. Thus, we performed a meta-analysis to explore the association between calcium intake and the risk of ovarian cancer. Pubmed, Embase and Web of Science were searched for eligible publications up to April 2017. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using the random-effects model. Small-study effect was estimated using Egger’s test and the funnel plot. Among 15 epidemiological studies involving 493,415 participants and 7453 cases eligible for this meta-analysis, 13 studies were about dietary calcium intake, 4 studies about dairy calcium intake and 7 studies about dietary plus supplemental calcium intake. When comparing the highest with the lowest intake, the pooled RRs of ovarian cancer were 0.80 (95% CI 0.72–0.89) for dietary calcium, 0.80 (95% CI 0.66–0.98) for dairy calcium and 0.90 (95% CI 0.65–1.24) for dietary plus supplemental calcium, respectively. Dietary calcium was significantly associated with a reduced risk of ovarian cancer among cohort studies (RR = 0.86, 95% CI 0.74–0.99) and among case-control studies (RR = 0.75, 95% CI 0.64–0.89). In subgroup analysis by ovarian cancer subtypes, we found a statistically significant association between the dietary calcium (RR = 0.78, 95% CI 0.69–0.88) and the risk of epithelial ovarian cancer (EOC). This meta-analysis indicated that increased calcium intake might be inversely associated with the risk of ovarian cancer; this still needs to be confirmed by larger prospective cohort studies. MDPI 2017-06-30 /pmc/articles/PMC5537794/ /pubmed/28665326 http://dx.doi.org/10.3390/nu9070679 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Song, Xingxing
Li, Zongyao
Ji, Xinqiang
Zhang, Dongfeng
Calcium Intake and the Risk of Ovarian Cancer: A Meta-Analysis
title Calcium Intake and the Risk of Ovarian Cancer: A Meta-Analysis
title_full Calcium Intake and the Risk of Ovarian Cancer: A Meta-Analysis
title_fullStr Calcium Intake and the Risk of Ovarian Cancer: A Meta-Analysis
title_full_unstemmed Calcium Intake and the Risk of Ovarian Cancer: A Meta-Analysis
title_short Calcium Intake and the Risk of Ovarian Cancer: A Meta-Analysis
title_sort calcium intake and the risk of ovarian cancer: a meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537794/
https://www.ncbi.nlm.nih.gov/pubmed/28665326
http://dx.doi.org/10.3390/nu9070679
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