Cargando…
Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial
We evaluated the effect of red ginseng on toxicity, health-related quality of life (HRQL) and survival after adjuvant chemotherapy in patients with epithelial ovarian cancer (EOC). A total of 30 patients with EOC were randomly assigned to placebo (n = 15) and red ginseng groups (n = 15). All patient...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537886/ https://www.ncbi.nlm.nih.gov/pubmed/28753932 http://dx.doi.org/10.3390/nu9070772 |
_version_ | 1783254268467216384 |
---|---|
author | Kim, Hee Seung Kim, Mi-Kyung Lee, Maria Kwon, Byung-Su Suh, Dong Hoon Song, Yong Sang |
author_facet | Kim, Hee Seung Kim, Mi-Kyung Lee, Maria Kwon, Byung-Su Suh, Dong Hoon Song, Yong Sang |
author_sort | Kim, Hee Seung |
collection | PubMed |
description | We evaluated the effect of red ginseng on toxicity, health-related quality of life (HRQL) and survival after adjuvant chemotherapy in patients with epithelial ovarian cancer (EOC). A total of 30 patients with EOC were randomly assigned to placebo (n = 15) and red ginseng groups (n = 15). All patients took placebo or red ginseng (3000 mg/day) for three months. Then, we compared changes of genotoxicity, HRQL and survival between the two groups. As a result, red ginseng reduced micronuclei yield in comparison with placebo despite no difference of binucleated cells index. Although red ginseng increased serum levels of alanine aminotransferase and aspartate aminotransferase significantly, they were within the normal value. Moreover, there were no differences in adverse events between placebo and red ginseng groups. In terms of HRQL, red ginseng was associated with improved emotional functioning and decreased symptoms of fatigue, nausea and vomiting, and dyspnea, reduced anxiety and interference affecting life and improved daytime somnolence. However, there was no effect of red ginseng on prognosis of EOC. Conclusively, red ginseng may be safe and effective to reduce genotoxicity and improve HRQL despite no benefit of survival in patients with EOC who received chemotherapy. |
format | Online Article Text |
id | pubmed-5537886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55378862017-08-04 Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial Kim, Hee Seung Kim, Mi-Kyung Lee, Maria Kwon, Byung-Su Suh, Dong Hoon Song, Yong Sang Nutrients Article We evaluated the effect of red ginseng on toxicity, health-related quality of life (HRQL) and survival after adjuvant chemotherapy in patients with epithelial ovarian cancer (EOC). A total of 30 patients with EOC were randomly assigned to placebo (n = 15) and red ginseng groups (n = 15). All patients took placebo or red ginseng (3000 mg/day) for three months. Then, we compared changes of genotoxicity, HRQL and survival between the two groups. As a result, red ginseng reduced micronuclei yield in comparison with placebo despite no difference of binucleated cells index. Although red ginseng increased serum levels of alanine aminotransferase and aspartate aminotransferase significantly, they were within the normal value. Moreover, there were no differences in adverse events between placebo and red ginseng groups. In terms of HRQL, red ginseng was associated with improved emotional functioning and decreased symptoms of fatigue, nausea and vomiting, and dyspnea, reduced anxiety and interference affecting life and improved daytime somnolence. However, there was no effect of red ginseng on prognosis of EOC. Conclusively, red ginseng may be safe and effective to reduce genotoxicity and improve HRQL despite no benefit of survival in patients with EOC who received chemotherapy. MDPI 2017-07-19 /pmc/articles/PMC5537886/ /pubmed/28753932 http://dx.doi.org/10.3390/nu9070772 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Hee Seung Kim, Mi-Kyung Lee, Maria Kwon, Byung-Su Suh, Dong Hoon Song, Yong Sang Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial |
title | Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial |
title_full | Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial |
title_fullStr | Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial |
title_full_unstemmed | Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial |
title_short | Effect of Red Ginseng on Genotoxicity and Health-Related Quality of Life after Adjuvant Chemotherapy in Patients with Epithelial Ovarian Cancer: A Randomized, Double Blind, Placebo-Controlled Trial |
title_sort | effect of red ginseng on genotoxicity and health-related quality of life after adjuvant chemotherapy in patients with epithelial ovarian cancer: a randomized, double blind, placebo-controlled trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537886/ https://www.ncbi.nlm.nih.gov/pubmed/28753932 http://dx.doi.org/10.3390/nu9070772 |
work_keys_str_mv | AT kimheeseung effectofredginsengongenotoxicityandhealthrelatedqualityoflifeafteradjuvantchemotherapyinpatientswithepithelialovariancancerarandomizeddoubleblindplacebocontrolledtrial AT kimmikyung effectofredginsengongenotoxicityandhealthrelatedqualityoflifeafteradjuvantchemotherapyinpatientswithepithelialovariancancerarandomizeddoubleblindplacebocontrolledtrial AT leemaria effectofredginsengongenotoxicityandhealthrelatedqualityoflifeafteradjuvantchemotherapyinpatientswithepithelialovariancancerarandomizeddoubleblindplacebocontrolledtrial AT kwonbyungsu effectofredginsengongenotoxicityandhealthrelatedqualityoflifeafteradjuvantchemotherapyinpatientswithepithelialovariancancerarandomizeddoubleblindplacebocontrolledtrial AT suhdonghoon effectofredginsengongenotoxicityandhealthrelatedqualityoflifeafteradjuvantchemotherapyinpatientswithepithelialovariancancerarandomizeddoubleblindplacebocontrolledtrial AT songyongsang effectofredginsengongenotoxicityandhealthrelatedqualityoflifeafteradjuvantchemotherapyinpatientswithepithelialovariancancerarandomizeddoubleblindplacebocontrolledtrial |