Cargando…

Respiratory Tract Infections and the Role of Biologically Active Polysaccharides in Their Management and Prevention

Respiratory tract infections (RTIs) are the most common form of infections in every age category. Recurrent respiratory tract infections (RRTIs), a specific form of RTIs, represent a typical and common problem associated with early childhood, causing high indirect and direct costs on the healthcare...

Descripción completa

Detalles Bibliográficos
Autores principales: Jesenak, Milos, Urbancikova, Ingrid, Banovcin, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537893/
https://www.ncbi.nlm.nih.gov/pubmed/28726737
http://dx.doi.org/10.3390/nu9070779
_version_ 1783254270115577856
author Jesenak, Milos
Urbancikova, Ingrid
Banovcin, Peter
author_facet Jesenak, Milos
Urbancikova, Ingrid
Banovcin, Peter
author_sort Jesenak, Milos
collection PubMed
description Respiratory tract infections (RTIs) are the most common form of infections in every age category. Recurrent respiratory tract infections (RRTIs), a specific form of RTIs, represent a typical and common problem associated with early childhood, causing high indirect and direct costs on the healthcare system. They are usually the consequence of immature immunity in children and high exposure to various respiratory pathogens. Their rational management should aim at excluding other severe chronic diseases associated with increased morbidity (e.g., primary immunodeficiency syndromes, cystic fibrosis, and ciliary dyskinesia) and at supporting maturity of the mucosal immune system. However, RRTIs can also be observed in adults (e.g., during exhausting and stressful periods, chronic inflammatory diseases, secondary immunodeficiencies, or in elite athletes) and require greater attention. Biologically active polysaccharides (e.g., β-glucans) are one of the most studied natural immunomodulators with a pluripotent mode of action and biological activity. According to many studies, they possess immunomodulatory, anti-inflammatory, and anti-infectious activities and therefore could be suggested as an effective part of treating and preventing RTIs. Based on published studies, the application of β-glucans was proven as a possible therapeutic and preventive approach in managing and preventing recurrent respiratory tract infections in children (especially β-glucans from Pleurotus ostreatus), adults (mostly the studies with yeast-derived β-glucans), and in elite athletes (studies with β-glucans from Pleurotus ostreatus or yeast).
format Online
Article
Text
id pubmed-5537893
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-55378932017-08-04 Respiratory Tract Infections and the Role of Biologically Active Polysaccharides in Their Management and Prevention Jesenak, Milos Urbancikova, Ingrid Banovcin, Peter Nutrients Review Respiratory tract infections (RTIs) are the most common form of infections in every age category. Recurrent respiratory tract infections (RRTIs), a specific form of RTIs, represent a typical and common problem associated with early childhood, causing high indirect and direct costs on the healthcare system. They are usually the consequence of immature immunity in children and high exposure to various respiratory pathogens. Their rational management should aim at excluding other severe chronic diseases associated with increased morbidity (e.g., primary immunodeficiency syndromes, cystic fibrosis, and ciliary dyskinesia) and at supporting maturity of the mucosal immune system. However, RRTIs can also be observed in adults (e.g., during exhausting and stressful periods, chronic inflammatory diseases, secondary immunodeficiencies, or in elite athletes) and require greater attention. Biologically active polysaccharides (e.g., β-glucans) are one of the most studied natural immunomodulators with a pluripotent mode of action and biological activity. According to many studies, they possess immunomodulatory, anti-inflammatory, and anti-infectious activities and therefore could be suggested as an effective part of treating and preventing RTIs. Based on published studies, the application of β-glucans was proven as a possible therapeutic and preventive approach in managing and preventing recurrent respiratory tract infections in children (especially β-glucans from Pleurotus ostreatus), adults (mostly the studies with yeast-derived β-glucans), and in elite athletes (studies with β-glucans from Pleurotus ostreatus or yeast). MDPI 2017-07-20 /pmc/articles/PMC5537893/ /pubmed/28726737 http://dx.doi.org/10.3390/nu9070779 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jesenak, Milos
Urbancikova, Ingrid
Banovcin, Peter
Respiratory Tract Infections and the Role of Biologically Active Polysaccharides in Their Management and Prevention
title Respiratory Tract Infections and the Role of Biologically Active Polysaccharides in Their Management and Prevention
title_full Respiratory Tract Infections and the Role of Biologically Active Polysaccharides in Their Management and Prevention
title_fullStr Respiratory Tract Infections and the Role of Biologically Active Polysaccharides in Their Management and Prevention
title_full_unstemmed Respiratory Tract Infections and the Role of Biologically Active Polysaccharides in Their Management and Prevention
title_short Respiratory Tract Infections and the Role of Biologically Active Polysaccharides in Their Management and Prevention
title_sort respiratory tract infections and the role of biologically active polysaccharides in their management and prevention
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537893/
https://www.ncbi.nlm.nih.gov/pubmed/28726737
http://dx.doi.org/10.3390/nu9070779
work_keys_str_mv AT jesenakmilos respiratorytractinfectionsandtheroleofbiologicallyactivepolysaccharidesintheirmanagementandprevention
AT urbancikovaingrid respiratorytractinfectionsandtheroleofbiologicallyactivepolysaccharidesintheirmanagementandprevention
AT banovcinpeter respiratorytractinfectionsandtheroleofbiologicallyactivepolysaccharidesintheirmanagementandprevention