Cargando…
Cell‐free DNA results lead to unexpected diagnosis
Maternal cell‐free DNA (cfDNA) results that are discordant with the diagnostic fetal karyotype should prompt further investigation. If deeper analysis of the cfDNA results demonstrates a “saw‐tooth” pattern characteristic of genome‐wide imbalance, maternal malignancy is suggested. Identifying the ma...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538058/ https://www.ncbi.nlm.nih.gov/pubmed/28781851 http://dx.doi.org/10.1002/ccr3.1051 |
_version_ | 1783254294889234432 |
---|---|
author | Smith, Jessica Kean, Victoria Bianchi, Diana W. Feldman, Gerald Petrucelli, Nancie Simon, Michael Gonik, Bernard |
author_facet | Smith, Jessica Kean, Victoria Bianchi, Diana W. Feldman, Gerald Petrucelli, Nancie Simon, Michael Gonik, Bernard |
author_sort | Smith, Jessica |
collection | PubMed |
description | Maternal cell‐free DNA (cfDNA) results that are discordant with the diagnostic fetal karyotype should prompt further investigation. If deeper analysis of the cfDNA results demonstrates a “saw‐tooth” pattern characteristic of genome‐wide imbalance, maternal malignancy is suggested. Identifying the maternal malignancy can, however, be difficult. |
format | Online Article Text |
id | pubmed-5538058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55380582017-08-04 Cell‐free DNA results lead to unexpected diagnosis Smith, Jessica Kean, Victoria Bianchi, Diana W. Feldman, Gerald Petrucelli, Nancie Simon, Michael Gonik, Bernard Clin Case Rep Case Reports Maternal cell‐free DNA (cfDNA) results that are discordant with the diagnostic fetal karyotype should prompt further investigation. If deeper analysis of the cfDNA results demonstrates a “saw‐tooth” pattern characteristic of genome‐wide imbalance, maternal malignancy is suggested. Identifying the maternal malignancy can, however, be difficult. John Wiley and Sons Inc. 2017-07-03 /pmc/articles/PMC5538058/ /pubmed/28781851 http://dx.doi.org/10.1002/ccr3.1051 Text en © 2017 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Case Reports Smith, Jessica Kean, Victoria Bianchi, Diana W. Feldman, Gerald Petrucelli, Nancie Simon, Michael Gonik, Bernard Cell‐free DNA results lead to unexpected diagnosis |
title | Cell‐free DNA results lead to unexpected diagnosis |
title_full | Cell‐free DNA results lead to unexpected diagnosis |
title_fullStr | Cell‐free DNA results lead to unexpected diagnosis |
title_full_unstemmed | Cell‐free DNA results lead to unexpected diagnosis |
title_short | Cell‐free DNA results lead to unexpected diagnosis |
title_sort | cell‐free dna results lead to unexpected diagnosis |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538058/ https://www.ncbi.nlm.nih.gov/pubmed/28781851 http://dx.doi.org/10.1002/ccr3.1051 |
work_keys_str_mv | AT smithjessica cellfreednaresultsleadtounexpecteddiagnosis AT keanvictoria cellfreednaresultsleadtounexpecteddiagnosis AT bianchidianaw cellfreednaresultsleadtounexpecteddiagnosis AT feldmangerald cellfreednaresultsleadtounexpecteddiagnosis AT petrucellinancie cellfreednaresultsleadtounexpecteddiagnosis AT simonmichael cellfreednaresultsleadtounexpecteddiagnosis AT gonikbernard cellfreednaresultsleadtounexpecteddiagnosis |