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Deferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the −1774delG polymorphism in the Abcc2 gene

This manuscript describes the case of a patient with sickle cell anemia who died of fulminant hepatitis after therapy with the iron chelator Deferasirox. The patient was homozygous for the −1774delG polymorphism in the Abcc2 gene, which raises the concern about the use of hepatotoxic drugs in this s...

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Detalles Bibliográficos
Autores principales: Braga, Caroline C. B., Benites, Bruno Deltreggia, de Albuquerque, Dulcineia M., Alvarez, Marisa C., Seva‐Pereira, Tiago, Duarte, Bruno K. L., Costa, Fernando F., Gilli, Simone C. O., Saad, Sara T. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538070/
https://www.ncbi.nlm.nih.gov/pubmed/28781827
http://dx.doi.org/10.1002/ccr3.1040
Descripción
Sumario:This manuscript describes the case of a patient with sickle cell anemia who died of fulminant hepatitis after therapy with the iron chelator Deferasirox. The patient was homozygous for the −1774delG polymorphism in the Abcc2 gene, which raises the concern about the use of hepatotoxic drugs in this specific context.