Deferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the −1774delG polymorphism in the Abcc2 gene

This manuscript describes the case of a patient with sickle cell anemia who died of fulminant hepatitis after therapy with the iron chelator Deferasirox. The patient was homozygous for the −1774delG polymorphism in the Abcc2 gene, which raises the concern about the use of hepatotoxic drugs in this s...

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Autores principales: Braga, Caroline C. B., Benites, Bruno Deltreggia, de Albuquerque, Dulcineia M., Alvarez, Marisa C., Seva‐Pereira, Tiago, Duarte, Bruno K. L., Costa, Fernando F., Gilli, Simone C. O., Saad, Sara T. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538070/
https://www.ncbi.nlm.nih.gov/pubmed/28781827
http://dx.doi.org/10.1002/ccr3.1040
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author Braga, Caroline C. B.
Benites, Bruno Deltreggia
de Albuquerque, Dulcineia M.
Alvarez, Marisa C.
Seva‐Pereira, Tiago
Duarte, Bruno K. L.
Costa, Fernando F.
Gilli, Simone C. O.
Saad, Sara T. O.
author_facet Braga, Caroline C. B.
Benites, Bruno Deltreggia
de Albuquerque, Dulcineia M.
Alvarez, Marisa C.
Seva‐Pereira, Tiago
Duarte, Bruno K. L.
Costa, Fernando F.
Gilli, Simone C. O.
Saad, Sara T. O.
author_sort Braga, Caroline C. B.
collection PubMed
description This manuscript describes the case of a patient with sickle cell anemia who died of fulminant hepatitis after therapy with the iron chelator Deferasirox. The patient was homozygous for the −1774delG polymorphism in the Abcc2 gene, which raises the concern about the use of hepatotoxic drugs in this specific context.
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spelling pubmed-55380702017-08-04 Deferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the −1774delG polymorphism in the Abcc2 gene Braga, Caroline C. B. Benites, Bruno Deltreggia de Albuquerque, Dulcineia M. Alvarez, Marisa C. Seva‐Pereira, Tiago Duarte, Bruno K. L. Costa, Fernando F. Gilli, Simone C. O. Saad, Sara T. O. Clin Case Rep Case Reports This manuscript describes the case of a patient with sickle cell anemia who died of fulminant hepatitis after therapy with the iron chelator Deferasirox. The patient was homozygous for the −1774delG polymorphism in the Abcc2 gene, which raises the concern about the use of hepatotoxic drugs in this specific context. John Wiley and Sons Inc. 2017-06-15 /pmc/articles/PMC5538070/ /pubmed/28781827 http://dx.doi.org/10.1002/ccr3.1040 Text en © 2017 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Braga, Caroline C. B.
Benites, Bruno Deltreggia
de Albuquerque, Dulcineia M.
Alvarez, Marisa C.
Seva‐Pereira, Tiago
Duarte, Bruno K. L.
Costa, Fernando F.
Gilli, Simone C. O.
Saad, Sara T. O.
Deferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the −1774delG polymorphism in the Abcc2 gene
title Deferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the −1774delG polymorphism in the Abcc2 gene
title_full Deferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the −1774delG polymorphism in the Abcc2 gene
title_fullStr Deferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the −1774delG polymorphism in the Abcc2 gene
title_full_unstemmed Deferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the −1774delG polymorphism in the Abcc2 gene
title_short Deferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the −1774delG polymorphism in the Abcc2 gene
title_sort deferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the −1774delg polymorphism in the abcc2 gene
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538070/
https://www.ncbi.nlm.nih.gov/pubmed/28781827
http://dx.doi.org/10.1002/ccr3.1040
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