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Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial

There is mounting evidence that aerobic exercise has a positive effect on cognitive functions in older adults. To date, little is known about the neurometabolic and molecular mechanisms underlying this positive effect. The present study used magnetic resonance spectroscopy and quantitative MRI to sy...

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Autores principales: Matura, S, Fleckenstein, J, Deichmann, R, Engeroff, T, Füzéki, E, Hattingen, E, Hellweg, R, Lienerth, B, Pilatus, U, Schwarz, S, Tesky, V A, Vogt, L, Banzer, W, Pantel, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538117/
https://www.ncbi.nlm.nih.gov/pubmed/28934191
http://dx.doi.org/10.1038/tp.2017.135
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author Matura, S
Fleckenstein, J
Deichmann, R
Engeroff, T
Füzéki, E
Hattingen, E
Hellweg, R
Lienerth, B
Pilatus, U
Schwarz, S
Tesky, V A
Vogt, L
Banzer, W
Pantel, J
author_facet Matura, S
Fleckenstein, J
Deichmann, R
Engeroff, T
Füzéki, E
Hattingen, E
Hellweg, R
Lienerth, B
Pilatus, U
Schwarz, S
Tesky, V A
Vogt, L
Banzer, W
Pantel, J
author_sort Matura, S
collection PubMed
description There is mounting evidence that aerobic exercise has a positive effect on cognitive functions in older adults. To date, little is known about the neurometabolic and molecular mechanisms underlying this positive effect. The present study used magnetic resonance spectroscopy and quantitative MRI to systematically explore the effects of physical activity on human brain metabolism and grey matter (GM) volume in healthy aging. This is a randomised controlled assessor-blinded two-armed trial (n=53) to explore exercise-induced neuroprotective and metabolic effects on the brain in cognitively healthy older adults. Participants (age >65) were allocated to a 12-week individualised aerobic exercise programme intervention (n=29) or a 12-week waiting control group (n=24). The main outcomes were the change in cerebral metabolism and its association to brain-derived neurotrophic factor (BDNF) levels as well as changes in GM volume. We found that cerebral choline concentrations remained stable after 12 weeks of aerobic exercise in the intervention group, whereas they increased in the waiting control group. No effect of training was seen on cerebral N-acetyl-aspartate concentrations, nor on markers of neuronal energy reserve or BDNF levels. Further, we observed no change in cortical GM volume in response to aerobic exercise. The finding of stable choline concentrations in the intervention group over the 3 month period might indicate a neuroprotective effect of aerobic exercise. Choline might constitute a valid marker for an effect of aerobic exercise on cerebral metabolism in healthy aging.
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spelling pubmed-55381172017-08-02 Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial Matura, S Fleckenstein, J Deichmann, R Engeroff, T Füzéki, E Hattingen, E Hellweg, R Lienerth, B Pilatus, U Schwarz, S Tesky, V A Vogt, L Banzer, W Pantel, J Transl Psychiatry Original Article There is mounting evidence that aerobic exercise has a positive effect on cognitive functions in older adults. To date, little is known about the neurometabolic and molecular mechanisms underlying this positive effect. The present study used magnetic resonance spectroscopy and quantitative MRI to systematically explore the effects of physical activity on human brain metabolism and grey matter (GM) volume in healthy aging. This is a randomised controlled assessor-blinded two-armed trial (n=53) to explore exercise-induced neuroprotective and metabolic effects on the brain in cognitively healthy older adults. Participants (age >65) were allocated to a 12-week individualised aerobic exercise programme intervention (n=29) or a 12-week waiting control group (n=24). The main outcomes were the change in cerebral metabolism and its association to brain-derived neurotrophic factor (BDNF) levels as well as changes in GM volume. We found that cerebral choline concentrations remained stable after 12 weeks of aerobic exercise in the intervention group, whereas they increased in the waiting control group. No effect of training was seen on cerebral N-acetyl-aspartate concentrations, nor on markers of neuronal energy reserve or BDNF levels. Further, we observed no change in cortical GM volume in response to aerobic exercise. The finding of stable choline concentrations in the intervention group over the 3 month period might indicate a neuroprotective effect of aerobic exercise. Choline might constitute a valid marker for an effect of aerobic exercise on cerebral metabolism in healthy aging. Nature Publishing Group 2017-07 2017-07-18 /pmc/articles/PMC5538117/ /pubmed/28934191 http://dx.doi.org/10.1038/tp.2017.135 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by-nc-sa/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Original Article
Matura, S
Fleckenstein, J
Deichmann, R
Engeroff, T
Füzéki, E
Hattingen, E
Hellweg, R
Lienerth, B
Pilatus, U
Schwarz, S
Tesky, V A
Vogt, L
Banzer, W
Pantel, J
Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial
title Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial
title_full Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial
title_fullStr Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial
title_full_unstemmed Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial
title_short Effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled SMART trial
title_sort effects of aerobic exercise on brain metabolism and grey matter volume in older adults: results of the randomised controlled smart trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538117/
https://www.ncbi.nlm.nih.gov/pubmed/28934191
http://dx.doi.org/10.1038/tp.2017.135
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