Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice

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Late-onset Alzheimer’s disease (AD) remains a medical mystery. Recent studies have linked it to impaired repair of aged neurons. Potential involvement of interleukin33 (IL33) in AD has been reported. Here we show that IL33, which was expressed by up to 75% astrocytes in the aged brains, was critical...

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Detalles Bibliográficos
Autores principales: Carlock, C, Wu, J, Shim, J, Moreno-Gonzalez, I, Pitcher, M R, Hicks, J, Suzuki, A, Iwata, J, Quevado, J, Lou, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538122/
https://www.ncbi.nlm.nih.gov/pubmed/28675392
http://dx.doi.org/10.1038/tp.2017.142
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