Why could a woman have three Trisomy 21 pregnancies? – a case report

Mosaicism, an important cause for recurrent T21, should be suspected in families with more than one affected child wishing to receive prenatal counseling. Fluorescence in‐situ hybridization analysis in a large number of cells and in different tissue samples is critical for detecting low‐level mosaic...

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Detalles Bibliográficos
Autores principales: Magalhães, Magda, Marques, Cecília, Ramos, Fabiana, Jardim, Ana, Franco, Sofia, Coelho, Filomena, Carreira, Isabel, Moura, Paulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538204/
https://www.ncbi.nlm.nih.gov/pubmed/28781828
http://dx.doi.org/10.1002/ccr3.997
Descripción
Sumario:Mosaicism, an important cause for recurrent T21, should be suspected in families with more than one affected child wishing to receive prenatal counseling. Fluorescence in‐situ hybridization analysis in a large number of cells and in different tissue samples is critical for detecting low‐level mosaicism and is a key prognostic factor.

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