Congenital myotonic dystrophy—an RNA-mediated disease across a developmental continuum

Thomas and colleagues (pp. 1122–1133) demonstrate severe dysregulation of developmentally regulated alternative splicing and polyadenylation in congenital myotonic dystrophy (CDM). In doing so, they also highlight the importance of these post-transcriptional processes during normal fetal muscle deve...

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Detalles Bibliográficos
Autores principales: Jagannathan, Sujatha, Bradley, Robert K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538429/
https://www.ncbi.nlm.nih.gov/pubmed/28717044
http://dx.doi.org/10.1101/gad.302893.117
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author Jagannathan, Sujatha
Bradley, Robert K.
author_facet Jagannathan, Sujatha
Bradley, Robert K.
author_sort Jagannathan, Sujatha
collection PubMed
description Thomas and colleagues (pp. 1122–1133) demonstrate severe dysregulation of developmentally regulated alternative splicing and polyadenylation in congenital myotonic dystrophy (CDM). In doing so, they also highlight the importance of these post-transcriptional processes during normal fetal muscle development. Finally, they generate and characterize a mouse model of CDM that lacks all three Muscleblind-like proteins.
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spelling pubmed-55384292017-12-01 Congenital myotonic dystrophy—an RNA-mediated disease across a developmental continuum Jagannathan, Sujatha Bradley, Robert K. Genes Dev Outlook Thomas and colleagues (pp. 1122–1133) demonstrate severe dysregulation of developmentally regulated alternative splicing and polyadenylation in congenital myotonic dystrophy (CDM). In doing so, they also highlight the importance of these post-transcriptional processes during normal fetal muscle development. Finally, they generate and characterize a mouse model of CDM that lacks all three Muscleblind-like proteins. Cold Spring Harbor Laboratory Press 2017-06-01 /pmc/articles/PMC5538429/ /pubmed/28717044 http://dx.doi.org/10.1101/gad.302893.117 Text en © 2017 Jagannathan and Bradley; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Jagannathan, Sujatha
Bradley, Robert K.
Congenital myotonic dystrophy—an RNA-mediated disease across a developmental continuum
title Congenital myotonic dystrophy—an RNA-mediated disease across a developmental continuum
title_full Congenital myotonic dystrophy—an RNA-mediated disease across a developmental continuum
title_fullStr Congenital myotonic dystrophy—an RNA-mediated disease across a developmental continuum
title_full_unstemmed Congenital myotonic dystrophy—an RNA-mediated disease across a developmental continuum
title_short Congenital myotonic dystrophy—an RNA-mediated disease across a developmental continuum
title_sort congenital myotonic dystrophy—an rna-mediated disease across a developmental continuum
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538429/
https://www.ncbi.nlm.nih.gov/pubmed/28717044
http://dx.doi.org/10.1101/gad.302893.117
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