Neat1 is a p53-inducible lincRNA essential for transformation suppression

The p53 gene is mutated in over half of all cancers, reflecting its critical role as a tumor suppressor. Although p53 is a transcriptional activator that induces myriad target genes, those p53-inducible genes most critical for tumor suppression remain elusive. Here, we leveraged p53 ChIP-seq (chroma...

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Detalles Bibliográficos
Autores principales: Mello, Stephano S., Sinow, Carolyn, Raj, Nitin, Mazur, Pawel K., Bieging-Rolett, Kathryn, Broz, Daniela Kenzelmann, Imam, Jamie F. Conklin, Vogel, Hannes, Wood, Laura D., Sage, Julien, Hirose, Tetsuro, Nakagawa, Shinichi, Rinn, John, Attardi, Laura D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538433/
https://www.ncbi.nlm.nih.gov/pubmed/28698299
http://dx.doi.org/10.1101/gad.284661.116

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