Cargando…

Endoscopic features of lymphoid follicles using blue laser imaging (BLI) endoscopy in the colorectum and its association with chronic bowel symptoms

BACKGROUND/AIM: In the colorectum, lymphoid follicles hyperplasia (LH) is sometimes observed as small, round, yellowish-white nodules. The novel image-enhanced endoscopy system named blue laser imaging (BLI) provides enhanced the contrast of surface vessels using lasers for light illumination. We in...

Descripción completa

Detalles Bibliográficos
Autores principales: Tahara, Tomomitsu, Takahama, Kazuya, Tahara, Sayumi, Yoshida, Dai, Horiguchi, Noriyuki, Kawamura, Tomohiko, Okubo, Masaaki, Nagasaka, Mitsuo, Nakagawa, Yoshihito, Urano, Makoto, Shibata, Tomoyuki, Tuskamoto, Tetsuya, Ieda, Hiro-o, Kuroda, Makoto, Ohmiya, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538676/
https://www.ncbi.nlm.nih.gov/pubmed/28763491
http://dx.doi.org/10.1371/journal.pone.0182224
_version_ 1783254384990224384
author Tahara, Tomomitsu
Takahama, Kazuya
Tahara, Sayumi
Yoshida, Dai
Horiguchi, Noriyuki
Kawamura, Tomohiko
Okubo, Masaaki
Nagasaka, Mitsuo
Nakagawa, Yoshihito
Urano, Makoto
Shibata, Tomoyuki
Tuskamoto, Tetsuya
Ieda, Hiro-o
Kuroda, Makoto
Ohmiya, Naoki
author_facet Tahara, Tomomitsu
Takahama, Kazuya
Tahara, Sayumi
Yoshida, Dai
Horiguchi, Noriyuki
Kawamura, Tomohiko
Okubo, Masaaki
Nagasaka, Mitsuo
Nakagawa, Yoshihito
Urano, Makoto
Shibata, Tomoyuki
Tuskamoto, Tetsuya
Ieda, Hiro-o
Kuroda, Makoto
Ohmiya, Naoki
author_sort Tahara, Tomomitsu
collection PubMed
description BACKGROUND/AIM: In the colorectum, lymphoid follicles hyperplasia (LH) is sometimes observed as small, round, yellowish-white nodules. The novel image-enhanced endoscopy system named blue laser imaging (BLI) provides enhanced the contrast of surface vessels using lasers for light illumination. We investigated the endoscopic features of LH observed by using BLI endoscopy and its association with chronic bowel symptoms. PATIENTS/METHODS: 300 participants undergoing colonoscopy for various indications were enrolled. Entire colorectum was observed by using BLI-bright mode with non-magnification view. LH was defined as well demarcated white nodules. Elevated LH with erythema was distinguished as LH severe. RESULTS: LHs were observed more clearly by using BLI-bright mode compared to conventional white light colonoscopy and were also histologically confirmed as intense infiltration of lymphocytes or plasmacytes. LH was observed in 134 subjects (44.6%) and 67 (22.3%) were LH severe. LH was associated younger age (Odds ratio (OR) = 1.05, 95%Confidence Interval (95%CI) = 1.03–1.07, P<0.0001) and chronic bowel symptoms including constipation, hard stools, diarrhea and loose stools (all LH: OR = 4.03, 95%CI = 2.36–6.89, P<0.0001, LH severe: OR = 5.31, 95%CI = 2.64–10.71, P<0.0001). LH severe was closely associated with both constipation associated symptoms (OR = 3.94, 95%CI = 1.79–8.66, P = 0.0007) and diarrhea associated symptoms (OR = 5.22, 95%CI = 2.09–13.05, P = 0.0004). In particular, LH severe in the ascending colon was strongly associated with bowel symptoms (P<0.0001). CONCLUSION: LH, visualized by using BLI endoscopy was associated with bowel symptom, raising the possibility of pathogenic role of this endoscopic finding in the functional lower gastrointestinal disorders.
format Online
Article
Text
id pubmed-5538676
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-55386762017-08-07 Endoscopic features of lymphoid follicles using blue laser imaging (BLI) endoscopy in the colorectum and its association with chronic bowel symptoms Tahara, Tomomitsu Takahama, Kazuya Tahara, Sayumi Yoshida, Dai Horiguchi, Noriyuki Kawamura, Tomohiko Okubo, Masaaki Nagasaka, Mitsuo Nakagawa, Yoshihito Urano, Makoto Shibata, Tomoyuki Tuskamoto, Tetsuya Ieda, Hiro-o Kuroda, Makoto Ohmiya, Naoki PLoS One Research Article BACKGROUND/AIM: In the colorectum, lymphoid follicles hyperplasia (LH) is sometimes observed as small, round, yellowish-white nodules. The novel image-enhanced endoscopy system named blue laser imaging (BLI) provides enhanced the contrast of surface vessels using lasers for light illumination. We investigated the endoscopic features of LH observed by using BLI endoscopy and its association with chronic bowel symptoms. PATIENTS/METHODS: 300 participants undergoing colonoscopy for various indications were enrolled. Entire colorectum was observed by using BLI-bright mode with non-magnification view. LH was defined as well demarcated white nodules. Elevated LH with erythema was distinguished as LH severe. RESULTS: LHs were observed more clearly by using BLI-bright mode compared to conventional white light colonoscopy and were also histologically confirmed as intense infiltration of lymphocytes or plasmacytes. LH was observed in 134 subjects (44.6%) and 67 (22.3%) were LH severe. LH was associated younger age (Odds ratio (OR) = 1.05, 95%Confidence Interval (95%CI) = 1.03–1.07, P<0.0001) and chronic bowel symptoms including constipation, hard stools, diarrhea and loose stools (all LH: OR = 4.03, 95%CI = 2.36–6.89, P<0.0001, LH severe: OR = 5.31, 95%CI = 2.64–10.71, P<0.0001). LH severe was closely associated with both constipation associated symptoms (OR = 3.94, 95%CI = 1.79–8.66, P = 0.0007) and diarrhea associated symptoms (OR = 5.22, 95%CI = 2.09–13.05, P = 0.0004). In particular, LH severe in the ascending colon was strongly associated with bowel symptoms (P<0.0001). CONCLUSION: LH, visualized by using BLI endoscopy was associated with bowel symptom, raising the possibility of pathogenic role of this endoscopic finding in the functional lower gastrointestinal disorders. Public Library of Science 2017-08-01 /pmc/articles/PMC5538676/ /pubmed/28763491 http://dx.doi.org/10.1371/journal.pone.0182224 Text en © 2017 Tahara et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Tahara, Tomomitsu
Takahama, Kazuya
Tahara, Sayumi
Yoshida, Dai
Horiguchi, Noriyuki
Kawamura, Tomohiko
Okubo, Masaaki
Nagasaka, Mitsuo
Nakagawa, Yoshihito
Urano, Makoto
Shibata, Tomoyuki
Tuskamoto, Tetsuya
Ieda, Hiro-o
Kuroda, Makoto
Ohmiya, Naoki
Endoscopic features of lymphoid follicles using blue laser imaging (BLI) endoscopy in the colorectum and its association with chronic bowel symptoms
title Endoscopic features of lymphoid follicles using blue laser imaging (BLI) endoscopy in the colorectum and its association with chronic bowel symptoms
title_full Endoscopic features of lymphoid follicles using blue laser imaging (BLI) endoscopy in the colorectum and its association with chronic bowel symptoms
title_fullStr Endoscopic features of lymphoid follicles using blue laser imaging (BLI) endoscopy in the colorectum and its association with chronic bowel symptoms
title_full_unstemmed Endoscopic features of lymphoid follicles using blue laser imaging (BLI) endoscopy in the colorectum and its association with chronic bowel symptoms
title_short Endoscopic features of lymphoid follicles using blue laser imaging (BLI) endoscopy in the colorectum and its association with chronic bowel symptoms
title_sort endoscopic features of lymphoid follicles using blue laser imaging (bli) endoscopy in the colorectum and its association with chronic bowel symptoms
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538676/
https://www.ncbi.nlm.nih.gov/pubmed/28763491
http://dx.doi.org/10.1371/journal.pone.0182224
work_keys_str_mv AT taharatomomitsu endoscopicfeaturesoflymphoidfolliclesusingbluelaserimagingbliendoscopyinthecolorectumanditsassociationwithchronicbowelsymptoms
AT takahamakazuya endoscopicfeaturesoflymphoidfolliclesusingbluelaserimagingbliendoscopyinthecolorectumanditsassociationwithchronicbowelsymptoms
AT taharasayumi endoscopicfeaturesoflymphoidfolliclesusingbluelaserimagingbliendoscopyinthecolorectumanditsassociationwithchronicbowelsymptoms
AT yoshidadai endoscopicfeaturesoflymphoidfolliclesusingbluelaserimagingbliendoscopyinthecolorectumanditsassociationwithchronicbowelsymptoms
AT horiguchinoriyuki endoscopicfeaturesoflymphoidfolliclesusingbluelaserimagingbliendoscopyinthecolorectumanditsassociationwithchronicbowelsymptoms
AT kawamuratomohiko endoscopicfeaturesoflymphoidfolliclesusingbluelaserimagingbliendoscopyinthecolorectumanditsassociationwithchronicbowelsymptoms
AT okubomasaaki endoscopicfeaturesoflymphoidfolliclesusingbluelaserimagingbliendoscopyinthecolorectumanditsassociationwithchronicbowelsymptoms
AT nagasakamitsuo endoscopicfeaturesoflymphoidfolliclesusingbluelaserimagingbliendoscopyinthecolorectumanditsassociationwithchronicbowelsymptoms
AT nakagawayoshihito endoscopicfeaturesoflymphoidfolliclesusingbluelaserimagingbliendoscopyinthecolorectumanditsassociationwithchronicbowelsymptoms
AT uranomakoto endoscopicfeaturesoflymphoidfolliclesusingbluelaserimagingbliendoscopyinthecolorectumanditsassociationwithchronicbowelsymptoms
AT shibatatomoyuki endoscopicfeaturesoflymphoidfolliclesusingbluelaserimagingbliendoscopyinthecolorectumanditsassociationwithchronicbowelsymptoms
AT tuskamototetsuya endoscopicfeaturesoflymphoidfolliclesusingbluelaserimagingbliendoscopyinthecolorectumanditsassociationwithchronicbowelsymptoms
AT iedahiroo endoscopicfeaturesoflymphoidfolliclesusingbluelaserimagingbliendoscopyinthecolorectumanditsassociationwithchronicbowelsymptoms
AT kurodamakoto endoscopicfeaturesoflymphoidfolliclesusingbluelaserimagingbliendoscopyinthecolorectumanditsassociationwithchronicbowelsymptoms
AT ohmiyanaoki endoscopicfeaturesoflymphoidfolliclesusingbluelaserimagingbliendoscopyinthecolorectumanditsassociationwithchronicbowelsymptoms