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Probiotics protect mice from CoCrMo particles-induced osteolysis

Wear particle-induced inflammatory osteolysis is the primary cause of aseptic loosening, which is the most common reason for total hip arthroplasty (THA) failure in the med- and long term. Recent studies have suggested an important role of gut microbiota (GM) in modulating the host metabolism and im...

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Autores principales: Wang, Zhenheng, Xue, Kaiwen, Bai, Maosheng, Deng, Zhantao, Gan, Jingjing, Zhou, Gang, Qian, Hongbo, Bao, Nirong, Zhao, Jianning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538695/
https://www.ncbi.nlm.nih.gov/pubmed/28794630
http://dx.doi.org/10.2147/IJN.S130485
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author Wang, Zhenheng
Xue, Kaiwen
Bai, Maosheng
Deng, Zhantao
Gan, Jingjing
Zhou, Gang
Qian, Hongbo
Bao, Nirong
Zhao, Jianning
author_facet Wang, Zhenheng
Xue, Kaiwen
Bai, Maosheng
Deng, Zhantao
Gan, Jingjing
Zhou, Gang
Qian, Hongbo
Bao, Nirong
Zhao, Jianning
author_sort Wang, Zhenheng
collection PubMed
description Wear particle-induced inflammatory osteolysis is the primary cause of aseptic loosening, which is the most common reason for total hip arthroplasty (THA) failure in the med- and long term. Recent studies have suggested an important role of gut microbiota (GM) in modulating the host metabolism and immune system, leading to alterations in bone mass. Probiotic bacteria administered in adequate amounts can alter the composition of GM and confer health benefits to the host. Given the inflammatory osteolysis that occurs in wear debris-induced prosthesis loosening, we examined whether the probiotic Lactobacillus casei could reduce osteolysis in a mouse calvarial resorption model. In this study, L. casei markedly protected mice from CoCrMo particles (CoPs)-induced osteolysis. Osteoclast gene markers and the number of osteoclasts were significantly decreased in L. casei-treated mice. Probiotic treatment decreased the M1-like macrophage phenotype indicated by downregulation of tumor necrosis factor α (TNF-α), interleukin (IL)-6 and inducible nitric oxide synthase (iNOS) and increased the M2-like macrophage phenotype indicated by upregulation of IL-4, IL-10 and arginase. Collectively, these results indicated that the L. casei treatment modulated the immune status and suppressed wear particle-induced osteolysis in vivo. Thus, probiotic treatment may represent a potential preventive and therapeutic approach to reduced wear debris-induced osteolysis.
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spelling pubmed-55386952017-08-09 Probiotics protect mice from CoCrMo particles-induced osteolysis Wang, Zhenheng Xue, Kaiwen Bai, Maosheng Deng, Zhantao Gan, Jingjing Zhou, Gang Qian, Hongbo Bao, Nirong Zhao, Jianning Int J Nanomedicine Original Research Wear particle-induced inflammatory osteolysis is the primary cause of aseptic loosening, which is the most common reason for total hip arthroplasty (THA) failure in the med- and long term. Recent studies have suggested an important role of gut microbiota (GM) in modulating the host metabolism and immune system, leading to alterations in bone mass. Probiotic bacteria administered in adequate amounts can alter the composition of GM and confer health benefits to the host. Given the inflammatory osteolysis that occurs in wear debris-induced prosthesis loosening, we examined whether the probiotic Lactobacillus casei could reduce osteolysis in a mouse calvarial resorption model. In this study, L. casei markedly protected mice from CoCrMo particles (CoPs)-induced osteolysis. Osteoclast gene markers and the number of osteoclasts were significantly decreased in L. casei-treated mice. Probiotic treatment decreased the M1-like macrophage phenotype indicated by downregulation of tumor necrosis factor α (TNF-α), interleukin (IL)-6 and inducible nitric oxide synthase (iNOS) and increased the M2-like macrophage phenotype indicated by upregulation of IL-4, IL-10 and arginase. Collectively, these results indicated that the L. casei treatment modulated the immune status and suppressed wear particle-induced osteolysis in vivo. Thus, probiotic treatment may represent a potential preventive and therapeutic approach to reduced wear debris-induced osteolysis. Dove Medical Press 2017-07-27 /pmc/articles/PMC5538695/ /pubmed/28794630 http://dx.doi.org/10.2147/IJN.S130485 Text en © 2017 Wang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Wang, Zhenheng
Xue, Kaiwen
Bai, Maosheng
Deng, Zhantao
Gan, Jingjing
Zhou, Gang
Qian, Hongbo
Bao, Nirong
Zhao, Jianning
Probiotics protect mice from CoCrMo particles-induced osteolysis
title Probiotics protect mice from CoCrMo particles-induced osteolysis
title_full Probiotics protect mice from CoCrMo particles-induced osteolysis
title_fullStr Probiotics protect mice from CoCrMo particles-induced osteolysis
title_full_unstemmed Probiotics protect mice from CoCrMo particles-induced osteolysis
title_short Probiotics protect mice from CoCrMo particles-induced osteolysis
title_sort probiotics protect mice from cocrmo particles-induced osteolysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538695/
https://www.ncbi.nlm.nih.gov/pubmed/28794630
http://dx.doi.org/10.2147/IJN.S130485
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