Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells

The human ether-a-go-go-related gene (hERG) potassium channel conducts rapid delayed rectifier potassium currents (I(Kr)) and contributes to phase III cardiac action potential repolarization. Drugs inhibit hERG channels by binding to aromatic residues in hERG helixes. Berberine (BBR) has multiple ac...

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Detalles Bibliográficos
Autores principales: Yu, Dahai, Lv, Lin, Fang, Li, Zhang, Bo, Wang, Junnan, Zhan, Ge, Zhao, Lei, Zhao, Xin, Li, Baoxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538702/
https://www.ncbi.nlm.nih.gov/pubmed/28763460
http://dx.doi.org/10.1371/journal.pone.0181823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538702/
https://www.ncbi.nlm.nih.gov/pubmed/28763460
http://dx.doi.org/10.1371/journal.pone.0181823

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