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Sarcolemmal distribution of I(Ca) and I(NCX) and Ca(2+) autoregulation in mouse ventricular myocytes

The balance of Ca(2+) influx and efflux regulates the Ca(2+) load of cardiac myocytes, a process known as autoregulation. Previous work has shown that Ca(2+) influx, via L-type Ca(2+) current (I(Ca)), and efflux, via the Na(+)/Ca(2+) exchanger (NCX), occur predominantly at t-tubules; however, the ro...

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Detalles Bibliográficos
Autores principales: Gadeberg, Hanne C., Kong, Cherrie H. T., Bryant, Simon M., James, Andrew F., Orchard, Clive H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538864/
https://www.ncbi.nlm.nih.gov/pubmed/28476922
http://dx.doi.org/10.1152/ajpheart.00117.2017