Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRβ inhibitors

BACKGROUND: Tumor angiogenesis, essential for tumor growth and metastasis, is tightly regulated by VEGF/VEGFR and PDGF/PDGFR pathways, and therefore blocking those pathways is a promising therapeutic target. Compared to sunitinib, the C(5)-Br derivative of 2-pyrrolidone-fused (2-oxoindolin-3-ylidene...

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Detalles Bibliográficos
Autores principales: Yang, Ting-Hsuan, Lee, Chun-I, Huang, Wen-Hsin, Lee, An-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539068/
https://www.ncbi.nlm.nih.gov/pubmed/29086859
http://dx.doi.org/10.1186/s13065-017-0301-5

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