Efficacy of Cefquinome against Escherichia coli Environmental Mastitis Assessed by Pharmacokinetic and Pharmacodynamic Integration in Lactating Mouse Model

This work investigates the pharmacodynamic effectiveness of cefquinome against environmental Escherichia coli mastitis infection, following an intramammary administration. We established the pharmacokinetic and pharmacodynamic (PK/PD) model in lactating mice. The PK/PD parameters were identified to...

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Autores principales: Yu, Yang, Fang, Jin-Tao, Sun, Jian, Zheng, Mei, Zhang, Qing, He, Jie-Shun, Liao, Xiao-Ping, Liu, Ya-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539083/
https://www.ncbi.nlm.nih.gov/pubmed/28824576
http://dx.doi.org/10.3389/fmicb.2017.01445
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author Yu, Yang
Fang, Jin-Tao
Sun, Jian
Zheng, Mei
Zhang, Qing
He, Jie-Shun
Liao, Xiao-Ping
Liu, Ya-Hong
author_facet Yu, Yang
Fang, Jin-Tao
Sun, Jian
Zheng, Mei
Zhang, Qing
He, Jie-Shun
Liao, Xiao-Ping
Liu, Ya-Hong
author_sort Yu, Yang
collection PubMed
description This work investigates the pharmacodynamic effectiveness of cefquinome against environmental Escherichia coli mastitis infection, following an intramammary administration. We established the pharmacokinetic and pharmacodynamic (PK/PD) model in lactating mice. The PK/PD parameters were identified to achieve an antibacterial efficacy as indicated by PD activity, cytokine expression and PK/PD simulation. From our findings, given an 200 μg/gland dose once daily can achieve a considerable therapeutic effectiveness in experimental circumstance.
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spelling pubmed-55390832017-08-18 Efficacy of Cefquinome against Escherichia coli Environmental Mastitis Assessed by Pharmacokinetic and Pharmacodynamic Integration in Lactating Mouse Model Yu, Yang Fang, Jin-Tao Sun, Jian Zheng, Mei Zhang, Qing He, Jie-Shun Liao, Xiao-Ping Liu, Ya-Hong Front Microbiol Microbiology This work investigates the pharmacodynamic effectiveness of cefquinome against environmental Escherichia coli mastitis infection, following an intramammary administration. We established the pharmacokinetic and pharmacodynamic (PK/PD) model in lactating mice. The PK/PD parameters were identified to achieve an antibacterial efficacy as indicated by PD activity, cytokine expression and PK/PD simulation. From our findings, given an 200 μg/gland dose once daily can achieve a considerable therapeutic effectiveness in experimental circumstance. Frontiers Media S.A. 2017-08-02 /pmc/articles/PMC5539083/ /pubmed/28824576 http://dx.doi.org/10.3389/fmicb.2017.01445 Text en Copyright © 2017 Yu, Fang, Sun, Zheng, Zhang, He, Liao and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Yu, Yang
Fang, Jin-Tao
Sun, Jian
Zheng, Mei
Zhang, Qing
He, Jie-Shun
Liao, Xiao-Ping
Liu, Ya-Hong
Efficacy of Cefquinome against Escherichia coli Environmental Mastitis Assessed by Pharmacokinetic and Pharmacodynamic Integration in Lactating Mouse Model
title Efficacy of Cefquinome against Escherichia coli Environmental Mastitis Assessed by Pharmacokinetic and Pharmacodynamic Integration in Lactating Mouse Model
title_full Efficacy of Cefquinome against Escherichia coli Environmental Mastitis Assessed by Pharmacokinetic and Pharmacodynamic Integration in Lactating Mouse Model
title_fullStr Efficacy of Cefquinome against Escherichia coli Environmental Mastitis Assessed by Pharmacokinetic and Pharmacodynamic Integration in Lactating Mouse Model
title_full_unstemmed Efficacy of Cefquinome against Escherichia coli Environmental Mastitis Assessed by Pharmacokinetic and Pharmacodynamic Integration in Lactating Mouse Model
title_short Efficacy of Cefquinome against Escherichia coli Environmental Mastitis Assessed by Pharmacokinetic and Pharmacodynamic Integration in Lactating Mouse Model
title_sort efficacy of cefquinome against escherichia coli environmental mastitis assessed by pharmacokinetic and pharmacodynamic integration in lactating mouse model
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539083/
https://www.ncbi.nlm.nih.gov/pubmed/28824576
http://dx.doi.org/10.3389/fmicb.2017.01445
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