Selective Sparing of Striatal Interneurons after Poly (ADP-Ribose) Polymerase 1 Inhibition in the R6/2 Mouse Model of Huntington’s Disease

Poly (ADP-ribose) polymerases (PARPs) are enzymes that catalyze ADP-ribose units transfer from NAD to their substrate proteins. It has been observed that PARP-1 is able to increase both post-ischemic and excitotoxic neuronal death. In fact, we have previously shown that, INO-1001, a PARP-1 inhibitor...

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Detalles Bibliográficos
Autores principales: Paldino, Emanuela, Cardinale, Antonella, D’Angelo, Vincenza, Sauve, Ilaria, Giampà, Carmela, Fusco, Francesca R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539174/
https://www.ncbi.nlm.nih.gov/pubmed/28824383
http://dx.doi.org/10.3389/fnana.2017.00061

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