Cargando…

Integrative whole-genome sequence analysis reveals roles of regulatory mutations in BCL6 and BCL2 in follicular lymphoma

The contribution of mutations in regulatory regions to tumorigenesis has been the subject of many recent studies. We propose a new framework for integrative analysis of genome-wide sequencing data by considering diverse genetic information. This approach is applied to study follicular lymphoma (FL),...

Descripción completa

Detalles Bibliográficos
Autores principales:	Batmanov, Kirill, Wang, Wei, Bjørås, Magnar, Delabie, Jan, Wang, Junbai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539289/ https://www.ncbi.nlm.nih.gov/pubmed/28765546 http://dx.doi.org/10.1038/s41598-017-07226-4

Ejemplares similares

Integrating whole genome sequencing, methylation, gene expression, topological associated domain information in regulatory mutation prediction: A study of follicular lymphoma
por: Farooq, Amna, et al.
Publicado: (2022)

BayesPI-BAR2: A New Python Package for Predicting Functional Non-coding Mutations in Cancer Patient Cohorts
por: Batmanov, Kirill, et al.
Publicado: (2019)

Identifying functional regulatory mutation blocks by integrating genome sequencing and transcriptome data
por: Yang, Mingyi, et al.
Publicado: (2023)

BayesPI-BAR: a new biophysical model for characterization of regulatory sequence variations
por: Wang, Junbai, et al.
Publicado: (2015)

IGAP-integrative genome analysis pipeline reveals new gene regulatory model associated with nonspecific TF-DNA binding affinity
por: Sahaf Naeini, Alireza, et al.
Publicado: (2020)

Relationship between BCL2 mutations and follicular lymphoma outcome in the chemoimmunotherapy era
por: Correia, Cristina, et al.
Publicado: (2023)

Mutational landscape of high-grade B-cell lymphoma with MYC-, BCL2 and/or BCL6 rearrangements characterized by whole-exome sequencing
por: Künstner, Axel, et al.
Publicado: (2021)

Predicting Variation of DNA Shape Preferences in Protein-DNA Interaction in Cancer Cells with a New Biophysical Model
por: Batmanov, Kirill, et al.
Publicado: (2017)

High-Grade B-Cell Lymphoma (HGBL) with MYC and BCL2 and/or BCL6 Rearrangements Is Predominantly BCL6-Rearranged and BCL6-Expressing in Taiwan
por: Tsai, Cheng-Chih, et al.
Publicado: (2021)

MYC/BCL2 double- and MYC/BCL2/BCL6 triple-hit follicular lymphomas associated with t(8;14;18)(q24;q32;q21)
por: Takeoka, Kayo, et al.
Publicado: (2022)

Dysregulation of autophagy in human follicular lymphoma is independent of overexpression of BCL-2
por: McCarthy, Aine, et al.
Publicado: (2014)

Significance of Bcl-2 and Bcl-6 immunostaining in B-Non Hodgkin's lymphoma
por: Mahmoud, Hanan Mohamed, et al.
Publicado: (2011)

Bcl6 expression specifies the T follicular helper cell program in vivo
por: Liu, Xindong, et al.
Publicado: (2012)

Follicular regulatory T (Tfr) cells with dual Foxp3 and Bcl6 expression suppress germinal center reactions
por: Chung, Yeonseok, et al.
Publicado: (2011)

DZNep-mediated apoptosis in B-cell lymphoma is independent of the lymphoma type, EZH2 mutation status and MYC, BCL2 or BCL6 translocations
por: Akpa, Chidimma Agatha, et al.
Publicado: (2019)

Comparison of germinal center markers CD10, BCL6 and human germinal center-associated lymphoma (HGAL) in follicular lymphomas
por: Goteri, Gaia, et al.
Publicado: (2011)

A Rare Case of BCL2-Positive Multiple Myeloma Complicated with Follicular Lymphoma
por: Tsutsumi, Yutaka, et al.
Publicado: (2022)

Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma
por: Dupont, Thibault, et al.
Publicado: (2015)

C-MYC, BCL2 and BCL6 Translocation in B-cell Non-Hodgkin Lymphoma Cases
por: Salam, Dayang Sharyati Datu Abdul, et al.
Publicado: (2020)

TdT Positive Lymphoma with MYC, BCL2 and BCL6 Rearrangements: A Review of Diagnosis and Treatment
por: Singh, Aditi, et al.
Publicado: (2022)

The epigenetic regulator CTCF modulates BCL6 in lymphoma
por: Batlle-López, Ana, et al.
Publicado: (2015)

Survivin co-ordinates formation of follicular T-cells acting in synergy with Bcl-6
por: Andersson, Karin M.E., et al.
Publicado: (2015)

t(14;18)-negative Follicular Lymphomas Are Associated with a High Frequency of BCL6 Rearrangement at the Alternative Breakpoint Region
por: Gu, Keni, et al.
Publicado: (2009)

IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2
por: Jandl, Christoph, et al.
Publicado: (2017)

Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma.
por: Pezzella, F., et al.
Publicado: (1992)

Inter- and intratumoral heterogeneity of BCL2 correlates with IgH expression and prognosis in follicular lymphoma
por: Barreca, A, et al.
Publicado: (2014)

Targeting BCL-W and BCL-XL as a therapeutic strategy for Hodgkin lymphoma
por: Adams, Clare M., et al.
Publicado: (2019)

Bcl6 Preserves the Suppressive Function of Regulatory T Cells During Tumorigenesis
por: Li, Yiding, et al.
Publicado: (2020)

Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19
por: Kaneko, Naoki, et al.
Publicado: (2020)

Clustering of the SOM easily reveals distinct gene expression patterns: results of a reanalysis of lymphoma study
por: Wang, Junbai, et al.
Publicado: (2002)

Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors
por: Li, Weiping, et al.
Publicado: (2019)

Primary cutaneous diffuse large B‐cell lymphoma, leg type with MYC/BCL2/BCL6 overexpression
por: Okada, Yosuke, et al.
Publicado: (2021)

Expression of c-Myc, Bcl2, Bcl6, and Cyclin D1 in High-Grade B-Cell Lymphoma
por: Ali, Seemal, et al.
Publicado: (2022)

Expression of bcl-2 protein in follicular lymphomas: a report from a south Indian hospital.
por: Thomas, S., et al.
Publicado: (1998)

Prognostic impact of diffuse large B-cell lymphoma with extra copies of MYC, BCL2 and/or BCL6: comparison with double/triple hit lymphoma and double expressor lymphoma
por: Huang, Sixia, et al.
Publicado: (2019)

Infrequent BCL10 Mutations in B‐Cell Non‐Hodgkin's Lymphomas
por: Takahashi, Hidenobu, et al.
Publicado: (1999)

Bcl10 mutations in malignancy
por: Dyer, M J S
Publicado: (1999)

Four genetic lymphoma-specific events (MYC, BCL2, BCL6 and CCND1) identified in a high grade B lymphoma case
por: Ittel, A, et al.
Publicado: (2015)

Primary follicular lymphoma of the epididymis positive for t(14;18)(q32;q21)/IGH-BCL2 and negative for BCL2 protein expression: a case report
por: Tralongo, Vincenzo, et al.
Publicado: (2012)

A p85α–osteopontin axis couples the ICOS receptor to sustained Bcl-6 expression by follicular helper and regulatory T cells
por: Leavenworth, Jianmei W., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_9ht5gede3lptqkvviki684st73