Calcium Ion Induced Structural Changes Promote Dimerization of Secretagogin, Which Is Required for Its Insulin Secretory Function

Secretagogin (SCGN), a hexa EF-hand calcium binding protein, plays key roles in insulin secretion in pancreatic β-cells. It is not yet understood how the binding of Ca(2+) to human SCGN (hSCGN) promotes secretion. Here we have addressed this question, using mass spectrometry combined with a disulfid...

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Detalles Bibliográficos
Autores principales: Lee, Jae-Jin, Yang, Seo-Yun, Park, Jimin, Ferrell, James E., Shin, Dong-Hae, Lee, Kong-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539292/
https://www.ncbi.nlm.nih.gov/pubmed/28765527
http://dx.doi.org/10.1038/s41598-017-07072-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539292/
https://www.ncbi.nlm.nih.gov/pubmed/28765527
http://dx.doi.org/10.1038/s41598-017-07072-4

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