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Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations

Accumulating evidence supports a role of the PI3K-AKT pathway in the regulation of cell motility, invasion and metastasis. AKT activation is known to promote metastasis, however under certain circumstances, it also shows an inhibitory activity on metastatic processes, and the cause of such conflicti...

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Detalles Bibliográficos
Autores principales:	Rao, Guanhua, Pierobon, Mariaelena, Kim, In-Kyu, Hsu, Wei-Hsun, Deng, Jianghong, Moon, Yong-Wha, Petricoin, Emanuel F., Zhang, Yu-Wen, Wang, Yisong, Giaccone, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539338/ https://www.ncbi.nlm.nih.gov/pubmed/28765579 http://dx.doi.org/10.1038/s41598-017-06128-9

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