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The Association of Low-Penetrance Variants in DNA Repair Genes with Colorectal Cancer: A Systematic Review and Meta-Analysis

OBJECTIVES: Approximately 35% of colorectal cancer (CRC) risk is attributable to heritable factors known hereditary syndromes, accounting for 6%. The remainder may be due to lower penetrance polymorphisms particularly of DNA repair genes. DNA repair pathways, including base excision repair (BER), nu...

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Detalles Bibliográficos
Autores principales:	Aggarwal, Nikhil, Donald, Neil D, Malik, Salim, Selvendran, Subothini S, McPhail, Mark JW., Monahan, Kevin J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Clinical and Systematic Reviews
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539343/ https://www.ncbi.nlm.nih.gov/pubmed/28749454 http://dx.doi.org/10.1038/ctg.2017.35

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