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Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection

Dengue virus (DENV) regulates sphingosine kinase (SK)-1 activity and chemical inhibition of SK1 reduces DENV infection. In primary murine embryonic fibroblasts (pMEFs) lacking SK1 however, DENV infection is enhanced and this is associated with induction of normal levels of interferon beta (IFN-β) bu...

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Detalles Bibliográficos
Autores principales:	Aloia, Amanda L, Calvert, Julie K, Clarke, Jennifer N, Davies, Lorena T, Helbig, Karla J, Pitson, Stuart M, Carr, Jillian M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539417/ https://www.ncbi.nlm.nih.gov/pubmed/28791126 http://dx.doi.org/10.1038/cti.2017.32

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