C-reactive protein gene rs1205 polymorphism is not associated with the risk of colorectal cancer

The relationship between C-reactive protein (CRP) gene rs1205 polymorphism and the risk of colorectal cancer (CRC) has been investigated previously. However, the results were conflicting. In the present study, we assessed whether CRP gene rs1205 polymorphism was associated with the risk of CRC by meta-analysis. We searched in PubMed, Embase, and the CNKI databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Seven original studies involving 4,181 cases and 10,601 controls analyzed the association between CRP gene rs1205 polymorphism and CRC risk. No significant association was found between CRP gene rs1205 polymorphism and CRC risk in this meta-analysis. Sensitivity analysis did not draw different findings. Stratification analyses of ethnicity, type of cancer, and genotype method also did not obtain any association between CRP gene rs1205 polymorphism and CRC risk. In conclusion, this meta-analysis indicates that CRP gene rs1205 polymorphism was not associated with the risk of CRC.