Development of a PrGO-Modified Electrode for Uric Acid Determination in the Presence of Ascorbic Acid by an Electrochemical Technique

An attractive electrochemical sensor of poly(3,4-ethylenedioxythiophene)/reduced graphene oxide electrode (PrGO) was developed for an electrochemical technique for uric acid (UA) detection in the presence of ascorbic acid (AA). PrGO composite film showed an improved electrocatalytic activity towards...

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Autores principales: Tukimin, Nurulkhalilah, Abdullah, Jaafar, Sulaiman, Yusran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539542/
https://www.ncbi.nlm.nih.gov/pubmed/28671562
http://dx.doi.org/10.3390/s17071539
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author Tukimin, Nurulkhalilah
Abdullah, Jaafar
Sulaiman, Yusran
author_facet Tukimin, Nurulkhalilah
Abdullah, Jaafar
Sulaiman, Yusran
author_sort Tukimin, Nurulkhalilah
collection PubMed
description An attractive electrochemical sensor of poly(3,4-ethylenedioxythiophene)/reduced graphene oxide electrode (PrGO) was developed for an electrochemical technique for uric acid (UA) detection in the presence of ascorbic acid (AA). PrGO composite film showed an improved electrocatalytic activity towards UA oxidation in pH 6.0 (0.1 M PBS). The PrGO composite exhibited a high current signal and low charge transfer resistance (R(ct)) compared to a reduced graphene oxide (rGO) electrode or a bare glassy carbon electrode (GCE). The limit of detection and sensitivity of PrGO for the detection of UA are 0.19 μM (S/N = 3) and 0.01 μA/μM, respectively, in the range of 1–300 μM of UA.
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spelling pubmed-55395422017-08-11 Development of a PrGO-Modified Electrode for Uric Acid Determination in the Presence of Ascorbic Acid by an Electrochemical Technique Tukimin, Nurulkhalilah Abdullah, Jaafar Sulaiman, Yusran Sensors (Basel) Article An attractive electrochemical sensor of poly(3,4-ethylenedioxythiophene)/reduced graphene oxide electrode (PrGO) was developed for an electrochemical technique for uric acid (UA) detection in the presence of ascorbic acid (AA). PrGO composite film showed an improved electrocatalytic activity towards UA oxidation in pH 6.0 (0.1 M PBS). The PrGO composite exhibited a high current signal and low charge transfer resistance (R(ct)) compared to a reduced graphene oxide (rGO) electrode or a bare glassy carbon electrode (GCE). The limit of detection and sensitivity of PrGO for the detection of UA are 0.19 μM (S/N = 3) and 0.01 μA/μM, respectively, in the range of 1–300 μM of UA. MDPI 2017-07-01 /pmc/articles/PMC5539542/ /pubmed/28671562 http://dx.doi.org/10.3390/s17071539 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tukimin, Nurulkhalilah
Abdullah, Jaafar
Sulaiman, Yusran
Development of a PrGO-Modified Electrode for Uric Acid Determination in the Presence of Ascorbic Acid by an Electrochemical Technique
title Development of a PrGO-Modified Electrode for Uric Acid Determination in the Presence of Ascorbic Acid by an Electrochemical Technique
title_full Development of a PrGO-Modified Electrode for Uric Acid Determination in the Presence of Ascorbic Acid by an Electrochemical Technique
title_fullStr Development of a PrGO-Modified Electrode for Uric Acid Determination in the Presence of Ascorbic Acid by an Electrochemical Technique
title_full_unstemmed Development of a PrGO-Modified Electrode for Uric Acid Determination in the Presence of Ascorbic Acid by an Electrochemical Technique
title_short Development of a PrGO-Modified Electrode for Uric Acid Determination in the Presence of Ascorbic Acid by an Electrochemical Technique
title_sort development of a prgo-modified electrode for uric acid determination in the presence of ascorbic acid by an electrochemical technique
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539542/
https://www.ncbi.nlm.nih.gov/pubmed/28671562
http://dx.doi.org/10.3390/s17071539
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AT abdullahjaafar developmentofaprgomodifiedelectrodeforuricaciddeterminationinthepresenceofascorbicacidbyanelectrochemicaltechnique
AT sulaimanyusran developmentofaprgomodifiedelectrodeforuricaciddeterminationinthepresenceofascorbicacidbyanelectrochemicaltechnique

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