β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis

PURPOSE: Previous research showed that the absence of β1-integrin from the mouse lens after embryonic day (E) 13.5 (β1MLR10) leads to the perinatal apoptosis of lens epithelial cells (LECs) resulting in severe microphthalmia. This study focuses on elucidating the molecular connections between β1-int...

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Detalles Bibliográficos
Autores principales: Wang, Yichen, Terrell, Anne M., Riggio, Brittany A., Anand, Deepti, Lachke, Salil A., Duncan, Melinda K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Lens
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539801/
https://www.ncbi.nlm.nih.gov/pubmed/28763805
http://dx.doi.org/10.1167/iovs.17-21721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539801/
https://www.ncbi.nlm.nih.gov/pubmed/28763805
http://dx.doi.org/10.1167/iovs.17-21721

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