Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities

Glycosylation of the immunoglobulin G (IgG)-Fc tail is required for binding to Fc-gamma receptors (FcγRs) and complement-component C1q. A variety of IgG1-glycoforms is detected in human sera. Several groups have found global or antigen-specific skewing of IgG glycosylation, for example in autoimmune...

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Detalles Bibliográficos
Autores principales: Dekkers, Gillian, Treffers, Louise, Plomp, Rosina, Bentlage, Arthur E. H., de Boer, Marcella, Koeleman, Carolien A. M., Lissenberg-Thunnissen, Suzanne N., Visser, Remco, Brouwer, Mieke, Mok, Juk Yee, Matlung, Hanke, van den Berg, Timo K., van Esch, Wim J. E., Kuijpers, Taco W., Wouters, Diana, Rispens, Theo, Wuhrer, Manfred, Vidarsson, Gestur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539844/
https://www.ncbi.nlm.nih.gov/pubmed/28824618
http://dx.doi.org/10.3389/fimmu.2017.00877

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