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Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project

Oxidative stress and antioxidants play a role in age-related diseases and in the aging process. We here present data on protein carbonyls, 3-nitrotyrosine, malondialdehyde, and cellular and plasma antioxidants (glutathione, cysteine, ascorbic acid, uric acid, α-tocopherol, and lycopene) and their re...

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Autores principales: Weber, Daniela, Stuetz, Wolfgang, Toussaint, Olivier, Debacq-Chainiaux, Florence, Dollé, Martijn E. T., Jansen, Eugène, Gonos, Efstathios S., Franceschi, Claudio, Sikora, Ewa, Hervonen, Antti, Breusing, Nicolle, Sindlinger, Thilo, Moreno-Villanueva, María, Bürkle, Alexander, Grune, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539926/
https://www.ncbi.nlm.nih.gov/pubmed/28804532
http://dx.doi.org/10.1155/2017/1401452
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author Weber, Daniela
Stuetz, Wolfgang
Toussaint, Olivier
Debacq-Chainiaux, Florence
Dollé, Martijn E. T.
Jansen, Eugène
Gonos, Efstathios S.
Franceschi, Claudio
Sikora, Ewa
Hervonen, Antti
Breusing, Nicolle
Sindlinger, Thilo
Moreno-Villanueva, María
Bürkle, Alexander
Grune, Tilman
author_facet Weber, Daniela
Stuetz, Wolfgang
Toussaint, Olivier
Debacq-Chainiaux, Florence
Dollé, Martijn E. T.
Jansen, Eugène
Gonos, Efstathios S.
Franceschi, Claudio
Sikora, Ewa
Hervonen, Antti
Breusing, Nicolle
Sindlinger, Thilo
Moreno-Villanueva, María
Bürkle, Alexander
Grune, Tilman
author_sort Weber, Daniela
collection PubMed
description Oxidative stress and antioxidants play a role in age-related diseases and in the aging process. We here present data on protein carbonyls, 3-nitrotyrosine, malondialdehyde, and cellular and plasma antioxidants (glutathione, cysteine, ascorbic acid, uric acid, α-tocopherol, and lycopene) and their relation with age in the European multicenter study MARK-AGE. To avoid confounding, only data from countries which recruited subjects from all three study groups (five of eight centers) and only participants aged ≥55 years were selected resulting in data from 1559 participants. These included subjects from (1) the general population, (2) members from long-living families, and (3) their spouses. In addition, 683 middle-aged reference participants (35–54 years) served as a control. After adjustment for age, BMI, smoking status, gender, and country, there were differences in protein carbonyls, malondialdehyde, 3-nitrotyrosine, α-tocopherol, cysteine, and glutathione between the 3 study groups. Protein carbonyls and 3-nitrotyrosine as well as cysteine, uric acid, and lycopene were identified as independent biomarkers with the highest correlation with age. Interestingly, from all antioxidants measured, only lycopene was lower in all aged groups and from the oxidative stress biomarkers, only 3-nitrotyrosine was increased in the descendants from long-living families compared to the middle-aged control group. We conclude that both lifestyle and genetics may be important contributors to redox biomarkers in an aging population.
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spelling pubmed-55399262017-08-13 Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project Weber, Daniela Stuetz, Wolfgang Toussaint, Olivier Debacq-Chainiaux, Florence Dollé, Martijn E. T. Jansen, Eugène Gonos, Efstathios S. Franceschi, Claudio Sikora, Ewa Hervonen, Antti Breusing, Nicolle Sindlinger, Thilo Moreno-Villanueva, María Bürkle, Alexander Grune, Tilman Oxid Med Cell Longev Research Article Oxidative stress and antioxidants play a role in age-related diseases and in the aging process. We here present data on protein carbonyls, 3-nitrotyrosine, malondialdehyde, and cellular and plasma antioxidants (glutathione, cysteine, ascorbic acid, uric acid, α-tocopherol, and lycopene) and their relation with age in the European multicenter study MARK-AGE. To avoid confounding, only data from countries which recruited subjects from all three study groups (five of eight centers) and only participants aged ≥55 years were selected resulting in data from 1559 participants. These included subjects from (1) the general population, (2) members from long-living families, and (3) their spouses. In addition, 683 middle-aged reference participants (35–54 years) served as a control. After adjustment for age, BMI, smoking status, gender, and country, there were differences in protein carbonyls, malondialdehyde, 3-nitrotyrosine, α-tocopherol, cysteine, and glutathione between the 3 study groups. Protein carbonyls and 3-nitrotyrosine as well as cysteine, uric acid, and lycopene were identified as independent biomarkers with the highest correlation with age. Interestingly, from all antioxidants measured, only lycopene was lower in all aged groups and from the oxidative stress biomarkers, only 3-nitrotyrosine was increased in the descendants from long-living families compared to the middle-aged control group. We conclude that both lifestyle and genetics may be important contributors to redox biomarkers in an aging population. Hindawi 2017 2017-07-19 /pmc/articles/PMC5539926/ /pubmed/28804532 http://dx.doi.org/10.1155/2017/1401452 Text en Copyright © 2017 Daniela Weber et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Weber, Daniela
Stuetz, Wolfgang
Toussaint, Olivier
Debacq-Chainiaux, Florence
Dollé, Martijn E. T.
Jansen, Eugène
Gonos, Efstathios S.
Franceschi, Claudio
Sikora, Ewa
Hervonen, Antti
Breusing, Nicolle
Sindlinger, Thilo
Moreno-Villanueva, María
Bürkle, Alexander
Grune, Tilman
Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project
title Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project
title_full Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project
title_fullStr Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project
title_full_unstemmed Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project
title_short Associations between Specific Redox Biomarkers and Age in a Large European Cohort: The MARK-AGE Project
title_sort associations between specific redox biomarkers and age in a large european cohort: the mark-age project
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539926/
https://www.ncbi.nlm.nih.gov/pubmed/28804532
http://dx.doi.org/10.1155/2017/1401452
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